Recording neural activity in mini-brains is easy

Your mini-brains have big potential! Discover the electrical activity of your neural organoids with Axion's Maestro Pro and Maestro Edge microelectrode array (MEA) systems.

Recent trends in developmental biology and disease-in-a-dish modeling highlight the value of using cell models that more accurately recapitulate the multicellular organization and structure of in vivo tissues, such as neural organoids, also known as mini-brains. However, can the complexity of these more advanced neural cell models be revealed with only cell imaging, gene expression analysis, or Western blots? The neurons may have the proper characteristics, but how do they function in a network? Using Maestro MEA technology, any scientist can now quickly and easily measure electrical network behavior in live cells at high throughput. Now there is nothing stopping you from exploring life’s circuitry.

What is a multiwell MEA assay?
Axion’s microelectrode array (MEA), also known as multielectrode array, plates have a grid of tightly spaced electrodes embedded in the culture surface of each well. Electrically active cells, such as neurons, can be cultured over the electrodes. Over time, as the cultures become established, they form cohesive networks and present an electrophysiological profile. The resulting electrical activity, spontaneous or induced firing of neurons, is captured from each electrode on a microsecond timescale providing both temporally and spatially precise data. 

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