ACE-I & ARBs | Mechanism of Action, Indications, Adverse Reactions, Contraindications

Ninja Nerds!

Join us for our discussion on ACE Inhibitors and ARBs as we continue our lecture series on cardiovascular pharmacology and how to treat Hypertension (HTN). During this lecture Professor Zach Murphy will go into detail on how Angiotensin Converting Enzyme inhibitors (ACE-I) along with Angiotensin II Receptor Blockers (ARBs) are used to lower and control high blood pressure.

Join this channel to get access to perks:

APPAREL |

DONATE

SOCIAL MEDIA

@NinjaNerdSci

#ninjanerd #ACEinhibitors #ARBs

[aserehtavlis]

I really appreciate your time and effort making all these videos. You're truly amazing and genius. You help me with my exams and really understand how things work. Stay safe and healthy.

[TheOldMayfieldPlace]

You are so clear in your teaching. I wish you had taught pharmacology when I was in pharmacy school. I am really enjoying your videos. After 30 years I've forgotten some of the specifics of MOAs of the drugs I dispense daily. It doesn't really come up when speaking to my patients, but is the stuff I geek out on.

[kimswartz]

You are definitely out here teaching me better than the school I pay tuition to... thank you!!

[loriakelly]

Haven't been to college in 35 years and I can follow you easily. Thank you for sharing your knowledge and style of teaching.

[daniellesoileau]

I swear I don’t even need to go to class because of you!!!! You truly have a gift!!

[hwasunfiower]

It feel like i experience heaven when i found your channel. This really helps me a lot ❤🔥

[paulroberts]

Boom! Drop the Mic! Wow, your videos are excellent! I am a DNP and studying for my AANP (FNP) exam. Your content is right on, and your manner of teaching is an extremely effective teaching style for so many types of learners! Thank you, what a great refresher and preparation for my exam!

[mohamedfathi]

At first, I want to thank you and all of your team for the great work and dedication to make these type of videos that is comprehensive and informative. However, I want to comment on some of the information presented:
1) The Receptor that is responsible for mediating most of the angiotensin II activity is called AT-1 receptor not AT-2 receptor and ARB act by specifically inhibiting AT-1
2) ARB class of drugs ends with the suffix SARTAN like valSARTAN, candeSARTAN etc
3) Continous and chronic elevation of Angiotension has a mitotic activity on vascular SMC and cardiac myocyte and that is why ACEI or ARB are beneficial for cardiac hypertrophy as it lower the progression of this process.
4) Renal effect of these drugs is by mainly antagonize the effect of ANG-II on efferent arteriole which will eventually leads to dilation and decrease intraglomerular pressure. By relieving the stress on glomeruli that is beneficial is case of nephrotic syndrome or kidney disease.Also that is why renal artery stenosis is contraindication as it will cause sever drop in glomerular pressure by decreasing blood flow from afferent arteriole and by vasodilatory effect of ACEI on efferent arteriole.

Thank you again for all your efforts. I hope you all the best.

[libertyblueskyes]

You have so clearly and specifically answered my questions about the heart failure I experienced and the drugs I am taking. My cardiologists spends about ten minutes with me, not enough time to thoroughly understand. So thank you from the depths of my heart for taking the time and effort to educate all of us.

[tuilikaandreas]

the sound of your laughter as you repeat the process is so comforting and reassuring :)

[MrAkooanaih]

he is a genius in explaining thinig, im supporting your channel and website thnk you

[christineb]

I am so happy I found your channel. I am confident your knowledge and way of explaining the medications along with mechanisms of action, contraindications, etc. will help me greatly in my adv pharm for adv practice nursing. Thank you for your brain.

[ajithmampitiya]

Sir, I have never across this type of teaching experience. Very interesting. Vast knowledge in short period. Highly appreciated. Never forgotten. Thank you very much. Triple gem bless you.

[annabelle]

You're the best teacher ever! Thank you

[brianedwards]

I have been following you for years and I almost passed up on this video for a shorter one because it's really late and I have to be up early in the morning but you woke me up with this video. Absolutely crushed it, man! I LOVE the content that you make because you really know how to perfectly scratch the itch of not just wanting to know that " 'x' does 'y' " but HOW it does it. Thank you so much for your content!

[CiaoColeG]

About to start clinical for my MSN in a month and I've been so scared because I'm in pediatrics and don't give BP meds and so many others... Your videos are AMAZING!!? I love your teaching style. It's so engaging I missed my turn while listening and driving yesterday 😄

[emilyyoung]

I love how it’s so easy to follow your videos for my nursing pharmacology class because of my strong A&P 1 and 2 background…that I also acquired through watching Ninja Nerd videos. 😂 Getting me through every part of my degree. 👏 🙌🏻

[filippetrovic]

I am so grateful for this video, thank you truly. It is so disappointing that there channels on youtube that explain things better than professors in universities.

[ariespitzfaden]

Most thought out and straight forward video on ACE inhibitors and ARBs. Zach, we salute you. I love it when you piece together the mechanisms of these drugs!

[sunshinejoy]

Thank u zach for making me understand this so quickly with ur beautiful illustrations and clear explanation...more love to u❤️❤️