Serotonin and Melatonin Synthesis | Tryptophan Metabolism

Lesson on Serotonin and Melatonin Synthesis from the amino acid Tryptophan. Tryptophan is an essential amino acid, which is used to produce the monoamine neurotransmitter serotonin and the hormone melatonin. Serotonin is important in regulation of mood, appetite and sleep in the central nervous system, whereas melatonin is produced in the pineal gland and is important in regulating circadian rhythms. In the process of converting tryptophan into serotonin and melatonin, several important cofactors are used including tetrahydrobiopterin, s-adenosyl methionine (SAM), and co-enzyme A. Vitamins B5 and B6 are also required for serotonin and melatonin synthesis.

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JJ

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)

Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[devvildogg]

Thank you for making this video! Also I am so grateful we live in an era where awesome people take time out of their day to upload videos like this. I didn’t think I would find such a video on this topic but this helped A TON!!!

[deannaflynn]

This is an absolute lifesaver right now. THANK YOU

[claudiochenlo]

I’m glad there are people explaining such interesting concepts with such simplicity.
Thank you for your clarity and knowledge!!

[BB-ndbe]

this is fantastic!! thank you so much, after years of being in traditional medicine, I am now learning more about functional medicine. I love it, it totally makes sense.

[ozzme]

I had the most vivid dreams when on a high Tryptophan diet!!

[senseofmindshow]

Thank you for the super clear explanation. This is going to be really useful for a project I'm working on!

[hraqhraq]

I recommend to improve the quality such video, is to mention the location of all these enzymes, namely Cytosolic, and for added clarity you also can mention the gene symbols of the enzymes, so the viewer can go and search for them better. Enzymes gene symbols are: TPH1 orTPH2 then DDC then AANAT then finally ASMT all are cytosolic, then the product which is either Serotonin or Melatonin will go to Vesicles via special channels like VMAT2
Thanks for the video

[njemilenantan]

Brilliant video. Used it to prove a point regarding melatonin and Seratonin. Keep up the good work.

[munawwarshaikh]

I've to give Biochemistry presentation tomorrow on Tyrosine & Tryptophan. Thanks man, you saved my butt 😉

[bluesquirrel]

Thank you! Are there any sources for this topic? Any pharmacology books?

[PKGAMERZM]

Feedback: compared to your video on Catecholamine synthesis, the thingy (the grps added/removed) you wrote on right hand side of your last slide ( 9:47 ) felt redundant (not needed) cz uve already written same thing (the rxns like hydroxylation, decarboxylation, acetylation) on left side. And the grps being added or removed u wrote on right side could be confused with the cofactors on their left side.

Anyways, SUPERLOVED BOTH OF YOUR VIDEOS, pls keep the great thing up, you're doing a fantastic job

[sfebus]

Excellent!! This helped so much with my Orgo 2 project!

[kenshey]

Error was not citing the production of melatonin in the gut for bacteria and produced for mitochondria.... Not just for sleep... Thought the body. To stop at sleep is a narrow statement

[gamacminisplits]

Priceless information! Very understandable for normal people!

[Craigdna]

Thank you for sharing as that was an excellent presentation.

[reinerwilhelms-tricarico]

Did you know this? - Glyphosate (aka Roundup, herbicide) suppresses a plant enzyme EPSPSthat plants need to synthesize tryptophane and phenylalanine, as well as tyrosine, leading to the death of the plant. But also: These three amino acids, forming the aromatic group of the amino acids are essential for the production of serotonin, dopamine, and melatonine.
Just saying.
(Now I would like to know how much decades of use of glyphosate have influenced the physiology of the plants we eat, and what this might mean for the mental health of humanity ).

[jooky]

Great video JJ! How long does this process take? Like if I took some tryptophan how long would it be before I had melatonin and serotonin in my brain?

[TomHendricksMusea]

What is the connection between gut microbes and the production of serotonin in plants and animals.

[indigopursue]

I still love this litterly I’m a young psychology student! And this is soooo clear and amazing great content very professional and legit🕉💯💯(5-ht2a receptor)

[Johann_]

Hello, very interesting video as usual, thank you very much!
When it comes to light, do you know which step does it block for melatonin synthesis ?