The Evolving World of RNA Editing with Dr. David Nelles

Up until recently, DNA has dominated the field of technological development. However, RNA is slowly but surely finding its place on the stage. Although it is more fragile, and therefore more difficult to handle, there are a multitude of benefits to working with RNA over DNA, and in today’s episode we are joined by Dr. David Nelles, who is going to open your mind to the power that lies within these special molecules. David has spent the majority of his career building technologies that recognize and change RNA in human cells, and as you’ll hear today, there are numerous benefits to the development of this kind of technology. In our discussion, we talk about how CRISPR is evolving and why it has taken over from other gene editing techniques, the differences between homology directed repair (HDR) and non homologous end joining (NHEJ), and some of the things that David is most excited about in the future of the incredibly diverse and fascinating RNA field.

Key Points From This Episode:

● Factors that caused CRISPR to dominate the gene editing space.
● David explains the difference between DNA and RNA, using a football analogy.
● The goal that David centered his PhD around.
● Variety that exists amongst RND molecules.
● Benefits of targeting RNA in diseased cells, rather than DNA.
● Why RNA lagged behind DNA in terms of technological developments.
● A theory about the role played by RNA in the past.
● Methods of RNA editing.
● Comparing homology directed repair (HDR) and non homologous end joining (NHEJ).
● David provides a breakdown of the various different guides and enzymes.
● Three kinds of vector systems, and how they work.
● Examples of the types of RNAs that exist.
● What David is excited about in the future of the RNA technology field.

Tweetables:

“DNA is the same throughout your body. Whereas, RNA is distinct among different cell types, among different tissues, among healthy versus diseased cells from moment to moment, whether you’re sleeping or whether you’re awake.”— @DeeNelles [0:06:43]


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[Omikoshi]

And yet the flagship ARKG fund continues to compromise mostly of tdoc which has nothing related to genomics. Missed both Moderna and Pfizer run up this year leveraging mRNA tech. Ark needs researchers with deeper understanding of the space. Not amateurs throwing money at the roulette table.

[golftownpro]

I only lasted eight minutes I couldn't handle the quality of the audio

[michaelwaynetucker]

This is quite simply the most exciting technological advance in human history. Everyone before us could only wish for this research-- Everyone after us will be forever grateful.

[nathanael]

Audio quality is quite poor and made it difficult to listen or understand at times

[tndiw]

Hello, what exchange can I use to buy SAND?

[cerdh]

Excellent interview! Thank you to the ARKK team. An open mind when it comes to science & cures. Envisioning precision medicine in prevention & cures. As God intended. In deepest grace & gratitude. This healthcare professional & inspired integrator is grateful this innovation has been developed when needed. It’s not always needed, the physical body is very much intuitive. Those in the science know. Thanks team ARKK!

[JohnBowl]

I bought ARKG today for $65 and change. I think I'll start buying a little every 2-3 weeks and enjoy the profits in a few years. Glad to see the negative comments. The more the better. It's usually a good indicator that a reversal is around the corner. Cathie, just keep doing what you're doing!

[progressreason_]

ARK needs to get their act straight on ARKG. This fund is in trouble as they are investing in some shady companies. Maybe some backdoor funds going to

[davidanalyst]

I made it halfway through. I know what DNA and RNA are, but Im having trouble paying attention because one guy acts like hes on crack and the woman is trying to make a podcast.

[yandrygonzalez]

Feels very bad I am not that deep in this etf and is hurting me lol and with inflation not coming down anytime soon this looks like a money pit. Ajajajaja we are screwed.

[MKlyfe]

Due to the lack of feedback from a thumbs down button..can someone say if this video is good or bad? Thanks!

[sauldmark]

Invest in mrna and bntx already! Arkg is a joke without it!

[asdasikdaisncxzinaskdnmf]

Thank you for sharing. Knocking out some of my daily goals while listening this Sunday!