Drug-Receptor Interactions: Affinity, Efficacy, CRCs & Antagonism

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In this lecture EKG is going to cover drug-receptor interactions.
We’ll explore important concepts like drug binding, affinity, efficacy, potency, and concentration response curves. We’ll also break down the role of agonist drugs and dive into the different types of antagonism.

Table of Contents:
0:00 Intro
0:22 Concept of Drug-Receptor Interaction
3:50 Affinity, Law of Mass Action & Equilibrium Dissociation Constant (KD)
11:55 Efficacy & Receptor States
16:50 Concentration-Response Curves (CRCs)
21:02 Emax & EC50
23:37 Potency
29:48 Subdivisions within Agonists: Full & Partial
31:22 Types of Antagonism - Competitive (Reversible & Surmountable) & Non-competitive (Irreversible & Insurmountable)

For educational purposes only; NOT medical or other advice.

Lecture Source:
Ritter, J., Flower, R.J., Henderson, G., Yoon Kong Loke and Rang, H.P. (2018). Rang and Dale’s Pharmacology. 9th ed. Endinburgh: Elsevier.

#pharmacodynamics #pharmacology #ekgscience

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please cross check where you explained the two ways an insurmountable antagonism can be formed. i think you interchange "antagonist" for agonist. you said the higher the affinity of the agonist instead of the higher affinity of the antagonist. please i need a feedback i'm a student and you are fantastic + remarkable and then excellent.

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