Physiology of Opioid Addiction: Advancements in CNS and Respiratory Endpoint Measurement

In this webinar sponsored by Data Sciences International, Dr. Ralph Lydic and Dr. Tally Largent-Milnes discuss the role of respiratory and neuroscience research in addressing the opioid epidemic. Dr. Ralph Lydic, professor of neuroscience and co-director of anesthesiology research at the University of Tennessee, presents data demonstrating the systemic and neurological effects of opioids on breathing and sleep in rodent models. Following, Dr. Tally Largent-Milnes, assistant professor of pharmacology at the University of Arizona, presents research investigating how cannabinoid receptors modulate opioid-induced respiratory depression in rodent models.

Key discussion topics include:
- How opiates induce changes in sleep and breathing
- Animal model selection: which mouse lines are most suitable for preclinical respiratory research?
- The scientific insight gained from simultaneously collecting plethysmography and telemetry signals in a single study
- Brain chemistry as the basis of physiology and behavior
- How opioids induce respiratory depression
- Which cannabinoids, if any, induce respiratory depression in preclinical models
- How the site of action determines how cannabinoid targeting agents interact with opioid-induced respiratory depression