Immunology - MHC I Processing

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[armandohasudungan]

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[krisztoballit]

Awesome work, the visualizations are very nice and it helped me a lot in understanding the processing. Thanks a lot!
Let me just add some corrections:
1.: Not only the infected cells express MHC-I proteins, but every nucleated cells. In case of virally infected cells or some tumour cells, actually, the level of MHC-I on the cell surface can be characteristically low, which will help the NK cell to recognize them and activate citotoxic processes. It is, also, the structure of antigene-bond MHC-I proteins that will be different so that it helps the CD8+ cells to recognize them, just as you explained on the video.
2.: You called the vesicle leaving the Golgi "endosome", which is incorrect. Only the endocytic vesicles that perform transport from the membrane to the lysosome are called endosomes. The vesicle carrying the MHC-I protein to the cell surface is simply a transport vesicle.

Also, other people have left remarks before (bacterial infection, ubiquitinization), so I wouldn't repeat those.

Apart from these small mistakes it is a really great video, thanks for making it again! Keep up the good work, you gained +1 follower!

[Ekiyi]

A few corrections:
First, MHC class I is expressed on all nucleated cells, not when the cell is infected. When the cell is infected, it actually decreases the MHC class I molecules it expresses.

Second, MHC class I typically presents intracellular antigens, i.e., viruses. MHC class II does the extracellular (bacteria)

[speakingtowind]

I am an RMT medical student and I these videos are very well done and the visual helps me retain and visualize for my self what is occurring. This is great keep them up you know your stuff and you are truly helping me to fully understand.

[robertanghelache]

i was stuck on this for 2 days, subscribed right away, amazing work

[Val-nbfv]

I was studying for about 3 hours presentation and didn't understand it at all. I watched your video and got it in 10 minutes. Thank you, you do awesome job!

[grayhero]

This video was super helpful,
I just want to note that MHC I is not CD8+ restricted because also NK cells can recognize them,
But the CD8+ cell or the CTL is MHC I restricted

[heidichoi]

Thank you very much for drawing everything out and uploading them! I got the human physiology exam tomorrow and I found your artworks are very useful!!! Im looking forward to more of your artworks.

[bestbug]

I'm a student from Korea.Your lecture showing process in pictorial way helps me a lot Really helps me god damn a lot.Shit i'd tried to understand by written text only and it took my 1 hour with giving nothingAfter I've watched it i thought 'Damn shit. why i wasted my single fucking hour' You have saved my test thanks. i will subscribe

[hania.]

My major is Genetics but i need to know some basic immunology and your videoes helped me a few times while i was completely frustrated. thanks a lot from Iran❤🇮🇷

[prabe]

it had been very difficult for me to understand all these stuffs.... but technology and you made it easier... thank you so much...

[DrNerdHKM]

Very nice. . You've simplified a very complicated lesson in 9 min!!!..
You are really talented..
Thanks. .

[Yukito]

Thank You so much man! Took me two hours to finish watching this video due to pausing and drawing and taking notes, but very much worth it!

[Brickkzz]

MHC class I is expressed all the time, not only whn a cell is infected!

[urikohn]

First of all I want to tell you that your videos are truly amazing, and I've passed over 10 classes from them !!!

[itsmybio]

Besttt Video sir. I watched it in 2019 for MSc Exam and again today For CSIR bcoz no any videos could Explain better than this. Thanks a lot sir for making these videos. 😊😊😊

[brendabaca]

Amazing! I am taking an intro to Immunology course at my university, and I had a homework of this and I have not had lecture yet about this, and your video really helped me! Nice drawings btw

Thank you very much!!

[prachipatil]

Sir your videos are very very useful..I always watch your videos to understand those things which I didn't understand in my class.
Your drawing and explanation is too good..I wish I could have a teacher like you.

[partypoodlemama]

Great visualization and explanation. Extremely helpful in elucidating antigen processing, presentation and recognition. Thank you!

[ferdousnessrine]

amazing video ! The lesson seems to me so hard but now everything is clear ! :D thank you