UK HSP Support Group 2020: Insights from large HSP cohort

This video was recorded on 1st August 2020.
Dr Channa Hewamadduma talks about the Hereditary Spastic Paraplegia work that he and his team do in Sheffield.
Introduction to HSP (02:31)
Clinical picture of HSP (05:45)
Details of Sheffield cohort (07:20)
Non-gait HSP symptoms - bladder, pain, mood, cognitive, optic (10:23)
Overlaps with other conditions (12:33)
SPG7 specifics (13:42)
Issues with vision - potential biomarker (18:22)
Mutation analysis - age of onset (21:29)
The Sheffield HSP clinic (25:03)
Future plans - gait biomarker (27:16)
Single sensor gait analysis (30:08)
Potential for predictions (31:55)
Trial-ready group of mildly affected patients (33:24)
Correlation of neuro-imaging with clinical picture (34:41)
Using work to inform patients (36:25)
SPG7 drug screening programme (37:16)
Imaging system to identify potential therapeutic targets (38:03)
Mouse and zebrafish models (40:54)
SPG15 gene therapy (41:25)
Summary (42:35)
HSP childrens clinic (43:20)
Thank you (43:40)

[joywaltz]

This was such a helpful presentation. Thank you. I am an American woman of British/Irish decent and this answers so many of my questions. I am 51 and experienced onset of symptoms at 38 years old.

[debrabremer]

This has been very interesting. Thank you for your research efforts. Are you aware of any similar centers in the United States?