6. Nucleic Acids

MIT 7.016 Introductory Biology, Fall 2018
Instructor: Barbara Imperiali

In this final lecutre of the Biochemistry unit, Professor Imperiali covers nucleotides and nucleic acids, discussing their structures and their importance as fundamental units for information storage and information transfer.

License: Creative Commons BY-NC-SA

[MrJeffryh]

She’s the best. It’s no easy task to wrest clarity from a complex reality, but she does it here. More Imperiali videos, please!

[learnbiotechnologyandmicrobiol]

I don't know the name of the Professor but she is simply outstanding both in her teaching method and energy and I am sure she will be the favorite of all students

[woloabel]

(On Sunday of January 29, 2023). In the Matter of Biochemistry of MIT Introductory Course of Biology; By PhD Barbara Imperiali; 1) Nucleic Acid in the Various Possible Molecular Structures (1 Encoding Information Function; 2) Energy Transfer (ATP); 3) Protein Biosynthesis (in the Functional Isomeric Form of RNA); Chemical Structure Therein in: 1) Purine (A Double Aromatic Ring Nucleobase); 2) Pyrimidine (A Heterochromic Ring Molecule); 3) Nucleobase Pairing (Adenine, Guanine [Purines]; Cytosine Thymidine [Pyrimidine]), A, Deoxyribose Monosaccharide (Pentose Sugar); And the Phosphate Backbone is the Primary (Non-Covalent Bonding; Hydrogen Bonds, Glycosidic Bones and Phosphodiester Bonding) Nucleotide Formation Chemistry; RNA Chemical Configuration Nevertheless Follows the Most Stabilizing Purine-Pyrimidine Complementarity Principle with The Exception Uridine Replaces Thymidine in RNA Synthesis Processes (mRNA, tRNA, rRNA [Ribosomal Related] and many other Formations; Conserved and Evolutionary Significance: 1) Perhaps only Covalently Bonded Carbohydrates are the only oldest precursors in Biochemical Molecules while Nucleic Acids are known to Travel through the Universe in Comets and Other Celestial Momenta (RNA theorized herein as The Oldest of Nucleic Acid); 2) Most Significant Biomolecule in Biological Evolution (Inheritance [Memory in Chemical Form] and Energy Biosynthesis; PhD Barbara Imperiali, es sehr gut zu wiederlernen und tiefich denken Mit ihnen uber Biochemie. Heil!

[kazifaizulhaque]

Important note:
1. Why is DNA anti parallel (5'-3'), why not the opposite?
Ans: Because of thermodynamics Stability & Good H bond
2. Which strand is more stable?
Ans: Strand that has max (G triple bond C) and max H bond.
3. Other than H bond what are the other forces that contribute on making a DNA structure stable?
Ans: Hydrophobic forces at each step can make a stable DNA structure ; proven by research.

[sambasivaraovejendla]

Hats off to your efforts Madam! Great energy and outstanding teaching! Supreme command of the subject!

[shouryasingh]

I was always afraid of topics related DNA and its structure and chemistry, but her lecture made everything so easy!

[chitutiringstone]

You're the best.
Watched from Zambia 🇿🇲🇿🇲

[ابنعمرالشريف]

I didn't know that there is professors like her are existed 🥺
Omg thank you so much ❤

[Astra_the_dragon_uwu]

watching this makes my previous lessons on biology/biochemistry make SO MUCH more sense. my professor skipped a lot of steps/explanation so it was more memorization than logic, kind of frustrating :( but this is great! thanks!

[sambasivaraovejendla]

Hi Madam! I am a great fan of your lectures! I love your accent and presentation skills! Thank you!

[devika]

I want actually thanks to this channel for providing such a great lacture . This lacture is really very help full for understanding

[heisenberg]

Thank u MIT, you upload this awsome learning video, the lecture is so active and i very amazed with her teaching.

[ashutoshkumarsingh]

Great professor.Listing 2nd time.very useful.

[buck]

Been looking all over youtube for one part that's better here than anywhere else: How do base-pair H bonds arise? Thank you!

[muhammadsiddiqui]

Really inspired and "affected" by her energy.

[danielsong]

Thanks so much for the lecture producer. Part of the knowledge has solved a perennial problem of mine, but please allow me to give an advice to the Photographer, would u please keep the len stable? The fast rotating picture dizzied me and I belive there is someone also has the same feeling with me.

[brainstormingsharing]

Absolutely well done and definitely keep it up!!! 👍👍👍👍👍

[scotthalpern]

These lectures are fantastic! A review for me but very well presented. Your students are lucky.

[rydrakeesperanza]

I've started to watch this playlist but I don't know what exactly this is; can someone please explain what part these whole lectures are of? Is it university beginning or something, maybe even repititions from what you learn in school? (At least here in Germany if you have physics and chemics you don't have biology from year 10-12) so I'm wondering. Still whatever is is it may be a little help for my future (hopefully I can start studying biology soon)
47:00
Looks like they had fun "playing" 🤔, maybe that compensates the boring parts of work if they had some 🤔

[dax]

Might one of the purposes of non-coding DNA be simply the stability of the molecule? Obviously there's much more to it than that. But if DNA sequences are unstable if they are too short... then it might make sense to pad them. Could be completely off track here, of course.