CF Foundation | Research Overview: Aspiration in Cystic Fibrosis

Aspiration occurs when liquids or other foreign substances enter the airways. In cystic fibrosis, GI-related aspiration can impact the lungs, particularly for people with advanced CF lung disease and those who are pre- or post-transplant. During this webinar, Jeff King, MD, Isabel Neuringer, MD, and Chris Velez, MD, discuss what is currently known about GI-related aspiration and share their ongoing work to better understand this important topic. This webinar was moderated by Laurel Avery, an adult with CF who is post-lung transplant.

Originally recorded October 25, 2022.

0:00 │Research Overview: Aspiration in CF
01:43 │ Overview of GI-Related Aspiration (GRASP) in CF
05:55 │ Impact of GRASP in advanced lung disease and post-transplant
11:41 │ Why is aspiration is difficult to diagnose?
14:07 │ What is the role of proton pump inhibitors (PPIs)?
16:28 │ What is the correct timing of testing for GRASP?
17:54 │ Priorities for future research questions
20:32 │ How did GRASP become a topic of focus for research?
23:44 │ What are some of the key takeaways so far?
26:05 │ What future research is planned in this area?
31:27 │ What is being done to help bring more GI specialists into CF?
35:02 │ What is the difference between GRASP and bronchiolitis obliterans syndrome (BOS)?
40:13 │ Is there any overlap in symptomology between GRASP and other conditions, such as heart failure? How can we tell the difference?
43:39 │ How does Trikafta impact GRASP and other GI-related complications?
47:04 │ How common is dumping syndrome in people who are post-transplant after anti-reflux surgery?
49:17 │ Can you comment on the continued need for enzymes after starting Trikafta?
52:03 │ How many hours before bed should you refrain from eating to prevent aspiration?
52:56 │ What are you most excited about for research in this area moving forward?