Extended Aromatase Inhibitor Risk/Benefit

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Hope S. Rugo, MD, and Ruth O’Regan, MD, discuss the toxicities, risk/benefit profile, and side effects of extended aromatase inhibitors in breast cancer.

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Maybe some women don't experience side effects, but I am so done taking them. I'm on my second one (Arimidex) because the first one (aromasin) gave me terrible side effects. After only being on Arimidex for a week, my ALT rose over 20 points. This crap is poisoning my body. My doctor told me to stop and then we'll repeat the ALT blood test in a week or so. I would rather live a shorter and happier/active life than take these drugs. The weight gain from only 8 1/2 months on them is ridiculous (and I'm not a big eater, mostly plant based meals, all home cooked meals, no processed crap, small portions, etc). Insomnia is terrible on these meds. I've developed a trigger thumb and plantar fasciitis. At stage 1, node negative, clear margins on lumpectomy, followed by bilateral mastectomy (my choice to be aggressive), I will take my chances rather than take AI's. The side effects aren't worth it to me. What the hell good is it to live horrible life on AI's for the slight chance that my life will be extended by months should a recurrence happen? There are no guarantees of a long life for anyone so live your life well in the present rather than hoping for a long future.

ALaughaday

Hormone therapy for breast cancer is tumour suppression. It doesn't kill cancer cells the way intravenous chemotherapy does. It incapacitates them.

MichelleLeeWhite

The AIS are toxic. Women with early stage breast cancer with low oncotype score---the toxicity may outweigh the benefits in my opinion. This was 8 years ago.

JJB-qd

Interesting. I've heard quite the opposite actually, that aromatase inhibitors do not cure or stop cancer and that they only induce tumour dormancy and the end survival statistics are not affected. So the advice was to avoid aromatase inhibitors as they cause other serious problems that you have stated here in your video.

wjc

I'm a poor metabilizer of CYP2D6. I cannot take Tamoxifen at all. Other IA's have raised my blood sugars +350. What can I do naturally? I heard taking zinc helps. Anyone?

MIlw

Young men are you go them to grow taller

EnoI

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