Pharmacology - DRUGS FOR ALZHEIMER'S DISEASE (MADE EASY)

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Alzheimer’s disease is a progressive neurodegenerative disorder that leads to symptoms of dementia. Current therapeutic options are limited to drugs that provide only mild symptomatic benefit. Alzheimer's drugs are believed to work by either preventing the breakdown of acetylcholine or blocking the toxic effects associated with excess glutamate in the brain. This pharmacology lecture covers topics such as pathophysiology of Alzheimer's disease, cholinergic hypothesis, amyloid hypothesis, Tau hypothesis, mechanism of action & side effects of cholinesterase inhibitors and NMDA receptor antagonist, future of Alzheimer's treatment. Drugs mentioned include; Donepezil, Rivastigmine, Galantamine, and Memantine.

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0:00 Pathophysiology of Alzheimer's disease
1:56 Cholinesterase inhibitors
4:00 NMDA receptor antagonist
5:24 Future of Alzheimer's treatment

[pharmacybyasim]

*Drugs for Alzheimer's disease* primarily focus on managing symptoms and slowing progression. *Cholinesterase inhibitors* (donepezil, rivastigmine, galantamine) boost communication between nerve cells, while memantine, an *NMDA receptor antagonist*, helps regulate glutamate activity. *Newer treatments*, like _monoclonal antibodies_, target amyloid plaques to slow cognitive decline.

[OswaldDigestiveClinic]

If you enjoyed this video, you may also want to know that there's been recent research that uses a functional medicine approach to find possible root causes of Alzheimer's Disease!

[smile-wuwm]

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[MedMadeSiriuslyeasy]

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[thuytien]

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[howtomedicate]

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[jannmikoingelrabagogamingc]

Thank you very much for this video! It provided me with the basic knowledge I need for the pharmacology of Alzheimer's disease.

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[avatarofdance]

This is such a great video. I only knew about the Tau and Beta Amyloid hypotheses.

There now is a monoclonal antibody that works to target Beta-amyloid plaques and help clear them. Although it does a great job clearing the plaques, it only slows progression of Alzheimers, and does nothing to reverse the problems associated with cognitive decline. Lecanemab has had successful trials AND been approved by the FDA for treatment to slow the progression of EARLY Alzheimers. It has not been tested on later stage alzheimer's patients.

[anirudhrawat]

I did some research and found out that NEPRILYSIN INHIBITORS are helpful. It is more efficient in destroying Beta Amyloid proteins and preventing plaque formation. However this is still not fully approved for clinical treatments. Would like to know your thoughts...

[Mara-ymxj]

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[patriciaandre]

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[davideserboni]

Memantine doesn't cause diarrhea and insomnia, it causes constipation and somnolence

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[robertrisk]

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[Jessorwhateva]

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