Using Synthetic Biology To Extend Lifespan With Dr. Nan Hao

In 2023, a study was published in the journal Science sharing a breakthrough within the longevity field. This study used synthetic biology to alter the gene networks of yeast cells, and what they found was incredible. They were able to increase the lifespan of yeast cells by 82% compared to control cells. Various media outlets have covered the study with the study’s findings sparking transformative advancements in the longevity field.

This episode is an in-depth discussion with the lead scientist who worked on this 2023 study—Dr. Nan Hao. Dr. Hao provides a behind-the-scenes look into the motivation and the science behind this study.

During the discussion with Dr. Hao, we go into detail about this novel paper. We ask him about the gene network he created, why he picked the genes he did, and how what he discovered can transform longevity science going forward.

Intro and Dr. Hao’s background (00:00-4:16)
Synthetic networks and oscillator gene networks → (4:17–14:34)
How the SIRT2 and HAP genes impact longevity → (14:35–17:48)
Dr. Hao’s research on SIRT2 and HAP → (17:49–26:26)
82% lifespan extension observed in Dr. Hao’s study → (26:27–31:52)
Cellular networks and stress → (31:52–35:44)
Intermittent fasting and autophagy → (35:45–41:09)
Heterogeneity in cancer cells → (41:10–48:00)
How stress impacts the body → (48:01–52:50)
Factors that impact our stress response → (52:51–55:13)
Top tip for optimal health (55:13–end)
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