TABLET COATING MCQ SOLUTION WITH EXPLANATION, IMPORTANT MCQ ON COATING PROCESS, TABLET DOSAGE FORM,

TABLET COATING
Tablet coating is a process by which an essentially dry, outer layer of coating material is applied to the surface of a dosage form in order to confer specific benefits over uncoated variety. 
Coatings may be applied to various oral dosage forms such as particles, powders, granules, crystals, pellets and tablets

TABLET COATING OBJECTIVE
Mask the test, odour and color
To provide chemical and physical protection
To control release of the drug
To improve elegance
To retard volatile substance
To separate incompatible drugs
To prevent gastric irritation
To convert liquid into free flowing solids-microencapsulation

TABLET COATING STEPS

TABLET COATING OBJECTIVE
Primary component involved in tablet coating Tablet properties
Surface should be smooth
Compressed sufficiently hard
Shape should be spherical or convex
All excess particles should be removed by shifting prior to coating

TABLET COATING EQUIPMENT
The standard coating pan
The perforate coating pan
Accela-Cota
Hi-coater system
The fluidized bed coater
Supercell™ Tablet Coater

THIS MCQ TEST NO 64
TOPIC: TABLET COATING
TABLET DOSAGE FORM
SUBJECT: PHARMACEUTICS

Sugar coating
Sugar coating as the name suggests is the process which involves application of sugar (sucrose) based coating solution for the tablets
Sugar coating Process Multistage Process involving 6 separate operations.
It involves the application of sugar solution with color for several times to give UNIFORM AND ELEGANT FILM.
The coating is water soluble and dissolves after swallowing

SUGAR COATING
The process of sugar coating involves successive deposition of aqueous sugar solution on  tablet cores as they are rotated and tumbled in a revolving pan by spraying sugar solution or suspensions into pans & drying off the solvent

Sealing (Waterproofing)
Sealing is done by applying a polymer based water impermeable coating solution by either ladling or spray techniques.
The polymers used are natural gums like shellac, acacia or derivatives of cellulose like cellulose acetate pthalate (CAP), PVAP, HPMC

shellac, zein, Oleicacid, PG, PEG4000, alcohol, methylene chloride also used
Zein is alcohol-soluble protein derivative.
Shellac is more effective(because of polymerization of shellac), But it lengthens tablet disintegration and dissolution times

Sealing in tablet coating
Sugar-coatings are aqueous formulations which allow water to penetrate directly into the tablet core and thus potentially affecting product stability and possibly causing premature tablet disintegration.
It enables sugar-coated product to exhibit modified-release pattern (extended release or delayed "enteric"- release characteristics).
To protect tablet core from adverse effect of moisture

Subcoating in tablet coating
1] Large quantities of sugar-coatings are usually applied to the tablet core for increasing the tablet weight by 50- 100%
2] It is done to provide the sealed tablet cores with round edges and to build up the core weight. It is achieved by adding a bulking agent such as Calcium carbonate, to the sucrose solution.
3] Antiadherents e.g. Talc may be added after partial drying to prevent sticking of the tablets together & To protect the tablet core from adverse effect of moisture

The sub coating stage results in tablets with rough surfaces.
To facilitate the color application (which requires smooth surface), sub coated tablets are smoothed out by a thick sucrose syrup coating.

Polishing of tablet
After the colour coating, the tablet surfaces show a dull or matt appearance.  
To achieve glossy finish, applications of waxes (beeswax carnauba wax) are employed

PRINTING OF TABLET
Different tablets could be identified by manufacturer' logo, product name, dosage strength or other appropriate code.
For sugar-coated tablets, such identification could be only achieved by printing process using special edible inks.

It is different from sugar coating in type of material used and thickness of coating.
In the film coating film former is used, it does not increase more than 2 – 5 % by weight of tablet
Two type of class
1. Non enteric tablet &
2. Enteric tablet

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