THE PROTEASOME, UBIQUITINATION, AND PROTEIN DESTRUCTION

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Sources:
The best article: "The Logic of the 26S Proteasome" (2018) - Collins and Goldberg
"E2 enzymes: more than just middle men" (2016) - Stewart et al.
"ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation" (2010) - Peth et al.
"The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors" (2001) - Myung et al.
"Linkage between ATP consumption and Mechanical unfolding during the Protein Processing Reactions of an AAA+ Degradation Machine" (2003) - Kenniston et al.
"JB Special Review - Recent Topics in Ubiquitin-Proteasome System and Autophagy" (2017) - Saeki
"Complete Subunit Architecture of the Proteasome Regulatory Particle" (2012) - Lander et al.
"AAA Proteins and the Origins of Proteasomal Protein Degradation" (2011) - Ammelburg
"Proteasomal AAA-ATP-ases: Structure and Function" (2012) - Bar-Nun and Glickman
"Proteasome System of Protein Degradation and Processing" (2009) - Sorokin et al.
Molecular Biology of the Cell (6th Edition) - Alberts, Johnson, Lewis, Morgan, Raff, Roberts, Walter

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Dude this is actually really educational. Thanks man <3

WhereismyCoffee
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*new protein is created* “life! I feel such purpose!”
*ubiquitin attaches* “kill me!”
“Awww shoooot”

dentongamble
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What a fantastic video. Congratulations on your content! Im only sorry to come across it today and not earlier.

emilysullivan
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Great explanation. Next can be autophagy

Dr._Dawit_Girma
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You are a life saver. Thank you so much! Keep up the good work!

daniellerehani
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Very simple understandable explanation even a layman can understand

Naveenkumar-wtqp
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great lesson. Please cover autophagy as well

aaquib
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wow!
this is awesome, thank you very much.
please cover p53 mutation

mbinyuisidiki
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Thanks for a great vid, really easy and very informative!

alexandersolodovnikov
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Thank you so much for this informative video 😍🤓

K_splace
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Fantastic video! Looking for the "that's another video" on disaggregation chaparones??

maryh_
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nice explained! add subtitles, helps a lot.

durunfelipe
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wonderful video could u tell us the program that u use to design this, please

mohammadjehad
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hye recently i need to do an experiment to include ubiquitin specific antibody as to check the whether my proteosomal inhibitor is working used on Hela cells... this will be a western blot... if you can kindly provide any demonstration on how would the gel be formulated and what will be the visualization and how can we read the results.

alveenamukhtiar
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Difference between Protein half life and Protein Degradation.

aayushibajaj