Poisonous Concoction Pathfinder: Full Guide (Path of Exile 2)

I hope the wait was worth it, tried to fit as much as I could into this video if you have any questions leave a comment!
SUPER IMPORTANT (Cant be changed after lvling)
*****For the venom crypt quests, take stun threshold in act 3 and chaos resistance in act 6****

Not a ton of info there. I don't work for mobalytics so I'm not about to write a thesis there for free (PoB when)

Timestamps:
00:00 Intro
00:18 Poisonous Concoction Overview
1:24 Gear Overview
3:45 Main Skills and Supports
4:51 No Comorbidity???
5:32 Other Skills and Supports
6:50 How I'm Sustaining Flask Charges
7:58 Skill Tree (use the written guide)
8:46 Survivability
10:20 The Downsides of Pathfinder
10:44 Future Damage Scaling $$$$$
11:41 Current Build Cost
11:50 Leveling (some info in written guide)
12:35 ***IMPORTAINT DISCLAIMER***

[KassSaiyajin]

I'm not affiliated with mobalytics so there isnt as much detail as my normal PoBs but should be more than enough. If you have any questions leave a comment.

This is an unprecedented time in the history of PoE2. Being able to play this game where almost nothing is solved and everything is constantly changing is amazing. Please take this build as a base to build on, sure you can just 1 for 1 copy it but if you find something cool try it out.

If you made it this far I hope you enjoy this build. This build wouldn't be nearly as good without the help and theorycrafting from commentors, so if you are one of those people, thanks for being willing to take the time to research to make a skill we all love good.

Thanks for watching.

[Bacon-egg-cheese]

My favorite part of this video is watching you hesitate to pick up any loot for like 5 seconds every time something worth picking up drops because of on death ptsd

[rhirune]

Thank you. Wanted to start a PConc since the update, but was waiting for your guide.

[jbrown]

So I just made it to Geonor for the 2nd time. 2nd attack stunned him, and he stayed down. This is so deliciously powerful! Really looking forward to making it more crazy as it levels up. 🤘😁👍

[Popopidopop]

Running the herald of plague adds to the spread radius so that with a decent lvl on it u get to like 3.3 meters, as well as hindering some mobs.
Quite worth 30 spirit for clear.

[jakecurry]

Thank you for the guide! This looks awesome and may be my first SSF project

[MrCiecio]

thank you!
Man i really hope your channel gonna grow!

[Ztlr]

Btw there are some really strong defensive nodes near CI that gives a total of 16% of damage taken from mana before life, its super strong for big hits which is pretty much the biggest weakness defensive wise for us and you can annoint another 10% for a total of 26% which is pretty much just 26% damage reduction, also you should have a decent enough mana pool because you need a lot of int for the build and your pconc doesn't even cost mana so sustaing it should be fine.

[keldon_champion]

Another nice thing is that this tree works as a generic poison tree as well and you could easily run gas arrow or something as well if you wanted so you could run 1 poison skills for clear and 1 for single target

[HerrmDogg]

looking forward to the leveling video guide!!!

[Greamzih]

Looks interesting. I've just started a poison ranger. I don't like following a guide since it''s super boring, that's why I like you attitude to give a general direction and focus on explanation rather than build details. Good job.

[zealdrive]

Honestly having a lot of fun after speccing into pconc right when I did 1st ascendency at level 26 on my 2nd char. For campaign stuff, not having much issue sustaining the flask charges and the bosses have been going down easily enough.

[kalle-malle]

click to move with a fast build like this is pure insanity

[Maaster]

Great video, thanks!

I cooked my PConc Char up myself after latest patch notes were out since it looked really strong - and it is! Im running pure Evasion as defense rn (Wanna go Acrobatics when I get to ~lv90) and skip the Connected Chemistry Ascendancy node - with the tree, the Fine Belt and the Alchemist Boon stuff, I dont run out of flask charges in mapping, and rarely during bosses. Still struggling a bit on single target but I hope by the time I hit lv90 and get my 6th link, that problem will be solved.

Overall I think hybrid Eva/ES will be strongest, since then we could run Grim Feast too to overcap ES, but imo that is pretty unneeded for mapping rn, and will also make the build a lot more expensive. I currently spent around 7 div I think in total, and 2 of those were buying Widowhail, trying to corrupt them for higher % lol.

Will play around and keep an eye out on your channel to get more ideas!

[RowanNo]

Would really enjoy seeing you fight a boss or 2 for these videos. Great build

[Cakasaur]

I really enjoy the build, currently levelling with it, lv 79 right now. Started using pconc from first ascendancy and it feels super smooth going through the campaign.

Some changes i made is that i skipped going for the extra chaos/wither cluster and flask sustain clusters, instead putting the points into defences (spectral ward and acrobatics evasion cluster) for more comfy, braindead playstyle.

For wither application, i am trying out dark effigy since for some reason it has the "projectiles" tag so it is benefiting from +levels to projectiles, might not be so good but i don't find myself withering enemies that often anyway since despair is much more consistent and effective.

Flask charge sustain has not been an issue for me so i turned off alchemist boon and instead opted to use Ghost dance and grim feast like the meta slave i am. You gain charges from killing mobs so unless you are throwing the pconc at thin air, shouldn't have an issue. For non-map bosses, just turn off grim feast and turn on alch boon.

4th asc, probably a long way for me, i'm getting traveller's wisdom instead. 62% flask charge gain is just not worth 6 passive points for me. Move speed penalty is no issue once you get a quiver with speed so stagger stepping is so much faster.

[Hermes]

Hey there, playing smth similar, i played around with the Corpsewade boots for this, its insane for the clear. Just some input :) Linking the Decompose with Plague and Magnified effect basically auto clears rituals and breaches. The single target dmg of PConc is insane, but clearing lacks imo. So i tried them and they slap on that build.

[kukuruzvitaliev]

Playing gas arrow poison rn, from my experience - evasion + es is the way, cause you can stack nice amount of int, giving access to a higher Despair lvls, and Grim Feast is too OP. Also, there's an alternative to use Dark affigy instead of RoA for wither. Downside is how often mobs will target it and break wither stacking, but upside is that totem will disable Proximal Tangibility on rares.

[Wespa]

An interesting unique that I love using for clear are the corpsewade iron greaves. While you do lose some survivability the added clear speed is big. Perfect for running lower difficulty maps.

[khalidbilal]

The corpsewade boots are insanely strong it literally clears maps