Challenges in Drug Development for ALS

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Chapters:
2:44 Choosing ideal drug target
18:45 Developing an ideal clinical endpoint
28:55 Navigating the regulatory landscape
49:30 New legislation to accelerate drug approval
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If stop codons are formed within CAG repeats, due to methylation followed by spontaneous deamination of cytosines in CAG so that C is transformed into T producing TAG, then perhaps decitabine or other inhibitors of methyltransferase could slow down the onset of diseases related to CAG repeats above the capacity of DNA glycosylase to excise T and fix errors

salvadorhirth
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What is the new treatment please tell me that
Als mnd

aghaagha-etif
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Wow amazing!!! Riluzole to the rescue.

diwakarkoirala