BRUGADA syndrome, from genetic mutation to sudden cardiac death, ESC 2022 guideline review

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00:00 Definition and Intro
00:40 Gen mutations in Brugada syndrome
01:30 Action potential phases in working myocardiocytes
04:11 Spike and Dome action potential morphology
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04:45 ITO channels distribution
06:42 Type 2 Brugada ECG pattern SADDLE-BACK
07:45 Type 1 Brugada ECG pattern COVED
08:48 Diagnostic criteria for BrS
09:30 Phase 2 reentry and short-coupled PVC
10:30 Polymorphic VT/VF and sudden cardiac death
11:40 Concealed Brugada syndrome and modulating factors
14:13 Diagnostic tests
15:20 Management of Brugada syndrome

This video about Brugada syndrome which includes molecular basis, electrophysiology and pathophysiology, relevant management approach.

Video about the action potential

Video about reentry

ESC guidelines Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death 2022

#usmle #step1 #step2 #medicine #pathology #physiology #education #medicalschool #pharmacology #biochemistry #highyield #lab #ecg #brugada #education #cardiology #medicalschool
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Bro this is amazing. I've been waiting for Phase 2 reentry and you didn't let down)
Btw Brugada syndrome concealing was new for me, and tbh I feel sane when I start to understand why exactly something works as it does.
Thanks for an amazing video. Keep it up

Andrew-nydl
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Great video! But why does further accentuation of the notch lead to a longer epicardial action potential?

krishvasa