Cisplatin; Mechanism of action ⑧

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How does cisplatin work to treat cancer?
which phase of cell cycle does it work at?

(Reference)
1. Manish a, et al. Cell Cycle-related Drug resistance. Clinical Cancer Research.Vol7, Issue 8. August 2001

2. Timothy C, et al. Third row transition metals for the treatment of cancer.Philosophical transactions of the royal society A. Vol 373, issue 2037March 2015

3. Shaloam D, et al.Cisplatin in cancer therapy: molecular mechanisms of action Eur J Pharmacol. 2014 Oct 5;0; 364-378

Music; Music is VFR
DNA image; Pixabay
Photo of bleomycin structure; wikipedia
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could you please explain the resistance of tumor to cisplatin

ipeksolmaz
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