New antiviral drug in trials

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Novel oral antiviral for SARS-CoV-2 progresses in Phase I trial, Protease inhibitor

Background science

Viral proteases are enzymes, endopeptidases

Encoded by the genetic material (DNA or RNA) of viral pathogens

Catalyze cleavage of specific peptide bonds in viral precursors

These proteolytic events are essential for the completion of the viral infectious cycle

Protease inhibitors, bind to a viral enzyme, called a protease

Prevent the virus from replicating

Protease inhibitors, used to treat HIV and hepatitis C

Assess tolerability and safety of multiple ascending doses of PF-07321332

Phase I study, healthy adults

Randomised, double-blind, sponsor-open, placebo-controlled, single- and multiple-dose escalation study in healthy adults evaluating the safety, tolerability and pharmacokinetics of PF-07321332.

Protease inhibitor, demonstrated potent in vitro antiviral activity against SARS-CoV-2 and other coronaviruses.

Could be prescribed orally at the first sign of infection

Pfizer also investigating an intravenously administered protease inhibitor, PF-07304814, in hospitalised patients with COVID-19.

November??

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I really wish Dr Campbell could do the daily national television updates instead of the Politicians and then the public would much better( and accurately) informed! Fantastic dedication to the providing us with the facts and to the truth!

colinknox

I heard they're gonna call it
*Iver-MIMIC-tin*
and, of course, it'll cost a helluva lot more. #GreedyBastards

oibal

We (apparently) already *Have* a drug which exhibits "antiviral properties against SARS Cov2"
Starts with "I"

rogerstarkey

With dr Campbell you have to know how to read between the lines, or listen between the sentences. He actually starts off by explaining that the companies don't want to invest in clinical trials for Ivermectin because there's no money to be made on a drug without patents. Thanks John. I'll stick with Ivermectin because it's results are incredibly good and it's safety profile incredibly well established.

pandemichackingchannel

hello John Ivermectin quote we've
talked about before on this channel
um because the pharmaceutical industry

has not got a vested interest in
investigating the
anti-viral efficacy of previously
existing
anti-viral drugs but these drugs still
need to be trialled
what this really means is governments
need to organize trials
for already existing
anti-viral drugs and it is really a bit
of a mystery why this is not being done
i don't really see why this is not
happening
because um if if an existing drug
that's out of copyright that the
pharmaceutical industry is
no longer particular claims on it can be
made generically by any manufacturer
then that could transform the pandemic

charlesmclaughlin

Why don’t they use Ivermectin? It seems to be very effective at getting rid of this thing even for long haulers!

alwayscurious

"....that could have transformed the pandemic situation..."
If Ivermectin had been handed out energetically this probably would have prevented a lot of the present fuss.

steenkigerrider

Use your imagination to know why no trials have been done by governments on existing repurposed drugs. How about conflict of interests for one?

YodaOI

I just want to say I have been watching for over a year. John Campbell and people here have made it easier on my heart. I have felt closer to the world. I cried for Italy at the start and worried for India and watched my country fail and watched people help others. It’s been up and down and although I will never truly feel and express the level of anger and pain I have deep down at least this has been a place of truth and peace. Yes, including the hard news days. Hard facts are hard but alternative facts are deadly. I could write a book about how you changed a small neighborhood and I am sure saved lives.

michellemaloney

Wow pushing one million subs now. Can't think of a more deserving channel to have such a following.

Always informative, always working hard for everybodies benefit. Absolute legend.

BaseDeltaZero

Ivermectin knock off. And the wheel keeps turning.

djackson

the GOVERNMENTS need to get the hell out of the way and allow personal MDS to treat their patients with the DRUGS already available on the market for seventy yrs.

rhontopo

Today i had my first dose of the vaccine, it was the AZ vaccine. I am happy i have had the first dose :)
Thank you so much Dr. Campbell for everything you have done for us lot over the last 14 months. You've educated us, kept us in the know (sometimes more in the know than the politicians it seems like) and i look forward to your videos every day, and when there's 2 in 1 day it's like a little present haha.

gazpf

You are right Dr. John, governments should move and organize trials for promising generic drugs like Ivermectin...etc. If Pfizer's drug works it would be hella expensive. Poor countries will not afford such drug.

Novak