Mechanism of NOTCH SIGNALING PATHWAY

The Notch signaling pathway is a highly conserved cell signalling system present in most multicellular organisms.[1] Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region.[2]

Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. It plays a major role in the regulation of embryonic development.

[hedayathabibzai]

Thank you sir but I think the third enzyme is gamma-secretase not alpha-secretase

[diksha]

Ur diagrams and explanation makes biology so easy to understand ...u've really helped me a lot during my graduation...keep up ur good work👍

[AgarwalBio]

Half an hour topic explained in 2 mins 👍👍

[michellew]

super helpful! thanks for making this!

[IanMahetiMbano]

This is so good Hussain, thank you again Sir.

[learningskills]

Thanks so much Sir seriously it's very helpful for me to understand #Notch signaling

[gopalkalwan]

Sir in place of alpha secretase it is gamma secretase otherwise i am a big fan of u

[austinkunch]

What's the difference between differentiation and cell fate?

[AnkeetKumar]

You speak like that of Shaukat Sir . .
I love you accent .

[ankitnegi]

Bhai pls video thodi slow bnawogy to thoda Shi rhgga thoda time consuming hogga bt pr smjny m asani hoggi🙂

[deekshasharma]

Can u plz name the proteins u mentioned in the end in nucleus? It's a bit unclear.

[vaishnavivaishu]

plz mention u r explaination in below box

[ruchitanavade]

The content is top class and your way of explanation is also good, but your language is not very this good content if the audience is not able to understand the topic, then whats the point of making the video, I hope you take it in a positive way.