Complexity of Different Tumors Revealed in 3D Maps for New Era of Cancer Treatment

Researchers at WashU Medicine in St. Louis have generated detailed views inside patient cancers, in three dimensions. The new maps reveal a tumor’s structure and function, down to the single cell, showing how all that may change when a tumor spreads.

Years of work went into the Tumor Atlas Network at Washington University School of Medicine. Co-senior author Li Ding, PhD, the David English Smith Professor of Medicine, began the research by using advanced technologies to study individual cells. The study involves 3D mapping of tumors and tumor microenvironments for analysis of how the maps change over time.

Ding's team generated 3D maps of the internal structures of multiple tumor types. The 3D analysis includes detailed data about breast, colorectal, pancreas, kidney, uterine and bile duct cancers.

The research is expected to spark a new era in the field of cancer biology. Ding said the studies have the potential to transform the way they understand and treat cancer in the future.


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