AlphaFold and the Grand Challenge to solve protein folding

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AlphaFold is DeepMinds latest breakthrough addressing the protein folding problem. Using an advanced Deep Learning architecture that achieves end-to-end learning of protein structures, this work is arguably one of the most influential papers of this decade and is likely to spark enormous advanced in computational biology and protein design. This video covers the entire architecture of the model as well as training principles that led to the incredible results of AlphaFold2!

::Chapters::
00:00 Intro
02:28 The Protein Folding Problem
05:29 AlphaFold1 revisited
06:10 Multiple Sequence Alignments (MSA)
08:10 Distograms
12:29 AlphaFold2
14:52 The Evoformer
19:07 The Structure Module
28:13 Zooming out: looking at the future

[julianW]

The sheer effort you put in your videos is mind blowing.

[FarrukhTickets]

Where do you go man!!! We need you to wrap our heads around Chat GPT 3, 45, 6, 7, 8, 9, 10... Not to mention, Bard, LamBda, LLama and others.
Come back to your channel.

[InturnetHaetMachine]

I just love that you actually go into the inner workings and important details of these papers in a coherent manner, and not just reading paper line by line and just repeating the information. Thanks for starting to make these videos again.

[anishahandique]

After going through most of the YouTube videos on this topic. This one was one of the best out of all. Very clear and crisp explanation. Thank you ❤

[vadimavkhimenia]

Please continue making videos. Your channel is great.

[navneetbung]

Thank you for explaining a complex architecture in such simple terms. Great work!

[linzhang]

Probably the best AlphaFold2 explained!

[johnf]

Gives a great overview before attempting to read the paper. Saved me a lot of work. Many thanks.

[yarrowflower]

Wow, you're uploading again! Great to see you!

[AkashMishra]

My dude is back, Amazing and well made video, Absolutely love watching your content

[suhagenetics]

Tears coming to my eyes! thank you so much. have to present the paper soon and got this... soooo many new terms for me as I have no idea about AI, ML, advanced computer language knowledge and this is helping so much I can't say. Haven't finished watching yet but going well. New subscriber. 😊

[joankim]

I love how this explains the reasoning behind all the steps. Most content just explains what and how, not why

[patriciobarletta]

Quick correction: AF2 deals with the protein structure prediction problem, not the protein folding problem.

[hongaivu]

The most educational informative video that I've ever watched on Youtube, bravo! I wonder what is your background?

[CAME]

One of the best a science communication YouTube channels ever!

[mohamedayoob]

A simple man here. Xander posts a video and I click it.

[UnpluggedPerformance]

Hey Xander, Toffe video man!! Leuk om iemand vanuit Belgie tegen te komen in de online data science en machine learning world! Ga zo door en super bedankt voor je inzet voor deze mooie video!!

[yaiirable]

Thanks for all that detail! It would have been interesting to hear a bit more about the potential applications of this technology at the start of the video

[samuelelwell]

Superb video, best one on AlphaFold 2 I have encountered by far!

[infoman]

Very interesting. It looks like Nature is alive -very much alive.