Can CRISPRa solve aging?

Can CRISPR be used in cellular reprogramming? Yes.

In this video we’ll take a look at a recent paper that shows CRISPR activation (CRISPRa) enables high fidelity reprogramming into human pluripotent stem cells. Given that there are many advantages to using CRISPRa such as expressing endogenous genes and multiplexing, could this be a superior approach to other methods being examined?

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TIMESTAMPS:
Intro - 00:00
Cellular Reprogramming - 00:30
Desirable reprogramming - 03:15
CRISPRa - 04:30
The paper - 06:30

References:

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

[ezekielsbot]

You’re awesome. Thank you for always believing in your intuition. It’s refreshing listening to people who actually know what they’re talking about!

[mmjvtnl]

Definitely want a sense of humor whenever I experience cellular reprogramming. I love your videos and look forward to your interviews as well! Please keep up the great work.

[machinized]

I want to drop everything and study genetics, that is so damn fascinating, thanks for another great video!

[georgbrindlinger]

Luv your sense of humor sheeky... made me giggle... thanks for all your great vids..

[themacso]

i love U I LOVE U I LOVE U. THANKS! Please upload anything u can about crispr gene reprogramming😊😊😊😊😊 THIS IS THE FUTURE, THIS WILL BECOME REALITY

[JR-htvy]

Always a pleasure to listen to you and always interesting. Keep us informed on these type of heath/life extending videos. I always enjoy your mice 🐭!

[JZGreengo]

I’m in so much physical pain, each day I want to die from my condition, I wonder if this could just fix my messed up nerves, I’d totally donate my body to research on this instead of having my sexuality and brain demolished by pharmaceutical drugs to treat my condition. I take nothing for my condition now and I hope I can participate in clinical trials one day for something like this, I’d rather die fighting than die doing absolutely nothing. I’m 22, not a 90 year old, I hope this seriously can not just reverse age but restore damaged bodies and autoimmune diseases.

I sound like a crazy person, I’m just in pain, desperate af and researching things to find hope in daily and I feel like if we restore aging we also restore the bodies normal functionality, who wants to live be old and young at the same time but still have the effects of back pain and cramping fingers that come from aging

[michaelvaughan]

whats your thoughts on intravenous sheep placenta. since sheep placenta is swimming around in hormones which make embryonic stem cells. do you think it can be transferred?

pls let me know if you make a video on it

[ioanmariandanila]

Reprogramming can produce stem cells or rejuvenated cells, at best. Some scientists believe that reprogramming cannot rejuvenate cells without making them first stem cells, without complete dedifferentiation. Stem cells maybe enhance regeneration. There is a stem cell theory of aging. Rejuvenated cells enhance organismal rejuvenation, at best, because they wouldn't change the old ratio of the cells. There is also a mutation theory of aging. Reprogramming cannot repair mutations, but CRISPR can... Maybe it is clear how could CRISPRa solve aging. And even if it cannot solve aging, it could extend lifespan, provided that it is safe.

[yanshen]

Is there anyone working on this with correcting Parkinson's disease? I would be very interested in that ... Michael

[ioanmariandanila]

Can, in principle, CRISPRa cellular reprogramming turn into induced pluripotential stem cells important neurons from memory neuronal networks?

[whatthefunction]

Just noticed that the drawing of your hair is a helix.

[OurBengals]

Diagnose for aging. Wish i could do that for a living.

[Azmarith]

You don't hate to say "I told you so" at all XD

[edwins]

We are indeed separated by a common language.

[AceKinG]

I do that every month. I Dry Fast for 3 days and feast on protein.

[MapleWorld]

I'd like to thank myself for liking this video. I am pretty awesome. Go me!

[HassanWorld]

This is amazing. Would love to have you on my channel.😇💯

[gregorysagegreene]

You're talking about giving an entire waterworld nano-planet the skeleton key to terraform itself. Not sure we understand enough yet. Zombie apocalypse might be mildest outcome.

[GMThePeople]

Cheekey, Sheekey, & top work on a most exciting & transformational topic! Kindly consider reproducing, for the common weal. One lass can only do so much. And perhaps spamming embryos + embryo sequencing & selection = superbabies is the surer way to a brighter future for our folks & fams: all this crispier Yarma-narka malarkey all gets a little complicated, don't it? C'mon, man! Regards, G.M. o/