Idelalisib for Previously Treated CLL

Jeffrey Jones, MD, MPH, assistant professor, Internal Medicine, section head, Chronic Lymphocytic Leukemia (CLL) research program, Ohio State University, discusses idelalisib (Zydelig) for previously treated CLL.

Jones says that idelalisib has been studied most extensively in combination with monoclonal antibodies, or in combination with chemotherapy. He and his team have been prescribing the drug since its approval, but with kinase inhibitors, sustained remissions will require continued therapy. This produces consequences for patients' health long term and financial health long term.

Jones and his colleagues are interested in rational combinations that can result in higher response rates and allow discontinuation therapy.