Vaccine Efficacy Versus Delta Variant: Real World Data (COVID 19 Update 133)

He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.

(This video was recorded on September 23, 2021)

TOPICS IN THIS VIDEO INCLUDE:

00:00 Introducing the research - How effective are approved COVID vaccines against Delta variant (United States)?
00:59 Report from the CDC - Interim Estimates of COVID 19 Vaccine Effectiveness
02:19 Definitions of “vaccinated,” “unvaccinated,” and “partially vaccinated”
03:06 Dr. Seheult explains the numbers and data for all COVID vaccines in the United States
07:56 Breakdown of efficacy by vaccine (Pzifer-BioNTech, Moderna, Janssen/Johnson & Johnson)

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Video Produced by Kyle Allred

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DISCLAIMER:

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.

#COVID19 #SARSCoV2 #Coronavirus

[MC---]

These videos should be broadcast on nightly news in there entirety. Most people don't go looking for content like this. They just listen to whatever talking head. Main stream media never explains this stuff in such detail.

[susannahwhite]

Appreciate all the work you do and for sharing it with us.

[polaris]

great info. No shaming, no politics, just straight academics.

[DanielaTaylorRealEstate]

Can you please help me understand why the hospitalization rate is so much higher for the vaccinated elderly? Could the vaccine be activating their underlying respiratory conditions?

[Fear]

Love the clean, un-politicized COVID and vaccine information!

[Huntr]

Thank you as always for the update. I generally dislike studies that start with Estimate and Adjusted For. I understand the purpose but would prefer to see the raw data along side the adjusted numbers.

[andrewroberts]

Would it be safe to get a Moderna booster if you’ve originally taken the 2 doses of the Pfizer Vaccine once it’s available since they operate on the same mechanism?

[haley]

Oh man I wish I understood this. Why is it so complex?
"VE was estimated using a test-negative design, adjusted for age, geographic region, calendar time (cubic spline with quartile knots), and virus circulation (percentage of SARS-CoV-2–positive results from testing within the counties surrounding the facility on the date of the event) and weighted for inverse propensity to be vaccinated or unvaccinated (calculated separately for each of the 10 VE models) using facility characteristics, sociodemographics, and underlying medical conditions."

[MrCalifornia]

Got vaccinated. My family all got delta. Most vaccinated. Got delta. No symptoms.

[leftymike]

If you had the vaccine, and then you catch the Delta variant. Do you still acquire natural immunity? Thank you for your time.

[beckybarnett]

How are they testing for the variant vs the initial strain of Covid?

[francyduska]

Thank you for presenting updates in such a clear manner. MedCram has been such a great source of solid information throughout this pandemic.

[Froven]

Now with all the "protection down to 15% after six months" it would be nice with an update about that. As many know the immunity is only one part of the bodys protection against covid-19.

[twinpop]

Love the channel, but can u comment on studies of nature immunity with those who have had the vaccine in terms of ethnicity?

[MadDoc-dfkw]

I can’t praise Medcram enough. Dr. S and company do a fantastic job of removing emotion and subjective ness to present the data. Never preachy or judgmental. I wish I had Dr. S in med school. Just a phenomenal teacher and a unique talent to convey some deep information.

[stephenfield]

great information - thank you. If the information is available it would be interesting to know how many of the people who were hospitalized had serious preexisting conditions.

[taaskeprins]

Thks for this vid! I see that an extract of the study is posted here. The original article is much more informative and you can find the link at the beginning of the article posted here. I cannot post links here; post will be deleted.
PLz look at the huge numbers of comorbidities in the study. These are very unhealthy people. There is a point of concern though. The CT of the PCR test is not mentioned. Other studies showed that for the delta variant, because of high viral loads, a low treshold (28..?) already confirms infection. Viral loads are lower in vaccinated people, so a higher treshold is needed for proper diagnoses. So if a low CT is used the unvacc group will turn out relative larger. Since this is an early print, perhaps this data can be added in the final article.

[smtimo]

Great info. But we already forgot why the covid vaccine is needed. The purpose of vaccine is to eliminate fatalities. Unfortunately, the data you presented there is no numbers representing how many death in vaccinated people vs unvaccinated people especially in elder people. Another question why Israel data is much different than USA? And how come Israel was able to use much bigger data set than in USA? And final question there is no data in ICU when it comes vaccinated vs unvaccinated. I remember I was reading the report from UK and could tell you it was more detailed.

[pauldellie]

Thank you for keeping the public informed.

[Malloc]

Roger, how about data comparing those with documented positive covid in the past and their susceptibility to Delta? Currently we're still advising immunization to those who are >90 days out from a documented covid illness. However, many of our patients are still hesitant to receive the vaccination for their personal reasons. One of their arguments is that, "well, I've already had covid, I have documented testing (or antibodies) I don't need vaccination." I am looking for any ammunition to help shoot this down or are they right after all? Is there data about this? Thanks.