Neuroscience - Long-Term Potentiation

Long-term potentiation is thought to be the molecular event that contributes to learning. Through synaptic plasticity LTP is established between various neurons, allowing for the learning process to occur. This video explains the molecular underpinnings leading up to LTP including both early and late phase changes. The video begins with the action potential and outlines the various stages required to establish synaptic changes. These synaptic changes lead to the formation of a stronger synapse and ultimately a stored memory within the brain.

This video is licensed under CC BY-NC-ND 4.0
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[CoWsGoNeighh]

It's funny to think that by watching this video I learn how memory works, and by doing so, the exact mechanisms that are displayed in this video IS HAPPENING IN MY HIPPOCAMPUS RIGHT NOW AS WE SPEAK, I CAN FEEL THE GROWTH OF NEW SYNAPSES BY THE INFLUX OF CA2+ IN THE POSTSYNAPTIC CA1 CELL. THE ACTION POTENTIALS ARE AT A ALL TIME HIGH RIGHT NOW.

[alejandrarincon]

I'm studying this the night before of my exam. I understand I'm screwed.

[MapleTree]

I've watched a lot of videos about neuroscience. A lot are good, some are great, this was magnificent!

[annieslice]

How is it that when one person (or three!) explain this it makes absolutely no sense and this makes it seem so super simple! I don't understand how people passed exams without google and youtube!! thank you so much!! xo

[stevenk]

3:26 Well thanks for reminding me while I'm studying for my exam today.

[Psnowdog]

A great deal of long-term depression happened while I was watching this

[TheSick]

This was great!!
I wasnt logged into my account, but i did after watching this video just so that i could "LIKE" and Comment on your video :)

[Urreasteve]

Wow! I can't express how glad I am that I found this video. My book was not able to explain it as clear as this presentation, my understanding of this subject just expanded because of this video. Thanks!

[imagination]

Slowest action potential I ever saw XD

[DerRebellTraumer]

The person or persons who created this video know exactly what they talk about - if anyone is doing psycho-biology this is a really helpful source since it explains simply - but in depth - what LTP is. For sure I am coming back for more, keep on doing these videos.

[Shadow]

Great video. I would suggest adding some text during the video to reiterate a few points, though.

[moiquiregardevideo]

How memories are formed for non students not studying their exams?
By the way, new synapses can form when a high frequency signal a present. Enough insignificant detail, now let's talk about how memories are formed by the opening of calcium channels... Which last only 24 hours.
That is enough for your exam.

[Jonnyiswhatweaimfor]

3:30 so how many times should I watch this video?

[Tphransis]

Being able to visualize this helps so much more than just reading and looking at pictures in the textbook. I don't think I'll ever forget this now, thanks !

[luciferin]

i have exam tomorrow and this is more clear than some of my lectures. THANK YOU <33

[syed]

so, practice doesn't make perfect, but makes magnesium get out of the way?

[zenzaiLD]

I'd like to thank all the people involved in making this very informative video. LTP is a rather complex process and you have managed to make a video that explains the phenomenon in a precise way which makes the concept easier to comprehend. Thank you!

[XreemeoX]

THANKS SOOOO MUCH, this helps a heck of a alot!!!! i can not thank you enough for making this clip!!!

[DraugSatan]

Brilliant! Dale Purves' "Neuroscience" offers some really in-depth stuff, but generally fails at mashing in small nails with big mallets, which we sometimes need when cramming. Succinct and precise, and gorgeously presented. Kudos!

[court]

Seriously this video was so awesome!!!! It was so helpful to see the representation of the long-term potentiation and hear the very clear explanation of what was happening. Definitely recommending this video to people in my class. Thank you!