Calcitonin Gene Related Peptide (CGRP) explained

Calcitonin Gene-Related Peptide (CGRP) is a neuropeptide that plays a significant role in various physiological processes in the body. It is primarily known for its involvement in pain modulation, blood vessel dilation, and inflammatory responses.
CGRP is a versatile neuropeptide with diverse roles in the body, and ongoing research continues to uncover its complexities and potential therapeutic applications.
In this video we will learn about:

-Origin: CGRP is derived from the calcitonin gene, and it is synthesized and released by neurons in both the central and peripheral nervous systems. There are two forms of CGRP: α-CGRP, primarily found in neurons in the central nervous system, and β-CGRP, found in the peripheral nervous system.

-Pain Modulation: CGRP is considered a potent vasodilator, meaning it relaxes blood vessels, particularly in the head and neck. It is implicated in the pathophysiology of migraines and other headache disorders. Elevated CGRP levels are often observed during migraine attacks.

-Neurotransmitter Role: CGRP acts as a neurotransmitter, facilitating communication between neurons. It plays a role in transmitting pain signals and sensory information.

-Inflammatory Responses: CGRP is also involved in inflammation. It can increase blood flow to injured or inflamed tissues, contributing to the recruitment of immune cells to the site of injury or infection.

-Therapeutic Target: Due to its role in migraines, CGRP has become a target for the development of migraine-specific medications. CGRP receptor antagonists and monoclonal antibodies that target CGRP or its receptor have been developed to prevent or reduce migraine attacks.

-Cardiovascular Effects: In addition to its role in pain and inflammation, CGRP has cardiovascular effects. It helps regulate blood pressure and may have cardioprotective properties.

-Clinical Relevance: Understanding the role of CGRP in various physiological processes has led to research and clinical applications. CGRP-targeted medications are used in the management of migraines, and further research continues to explore its potential in pain management and other areas of medicine.