AMYLOIDOSIS: PART 2: Pathogenesis & Classification

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AMYLOIDOSIS 2

PATHOGENESIS: Basic Mechanism
Abnormal folding of proteins/ Misfolded proteins

Mechanism of damage to the tissues
Pressure effect: leading to atrophy
Accumulation in vessel wall : Leading to ischemia and also increased permeability
Direct cytotoxicity: eg, Amyloidogenic light chain accumulation n cardiac cells
Prefibrillar oligomers: are found be more injurious than actual fibrils. In Alzheimer's and ATTR Amyloidosis

Localised amyloidosis
Limited to a single tissue or organ
Can be only microscopic foci or may be evident grossly as nodular masses
The common sites: lung, larynx, skin, bladder, tongue etc.
Microscopic findings: Lymphocytes and plasma cells can be seen in the periphery of amyloid deposits.
Some cases , the amyloid consists of AL protein

[MMBBS]

Sir plzzz cover all of such topics. Many students waiting for that thanxxxx 😍

[gopikaunni]

Watching all these during xam times really make me regret missing all those lectures at clg thank u for making these videos

[tulasibolisetty]

Thats such a nice video.... It took me a day long to read and inspite of that couldnt understand. Tons of thanks for making this video. You made it really easier and understanding. Your voice is fantastic though 😁

[saloniparekh]

The best vedio on amyloidosis...thankyou so much
May God bless u

[bhoomikagoel]

Great videos. It's the end of my second year and finally now I have been able to understand the concepts of amyloidosis. Thank you

[DrVinisha]

Very informative and standard contents explained in a perfect way👍

[komalsattar]

When it was v v v help full for me ( dermatologist resident).. Thank you so much ❤️

[yogavardhang]

Sir.... I don't known u are still active....but keep the videos coming ... they are really helpful 😇

[shivanichhabra]

Amyloidosis care pack of planet Ayurveda is the best treatment of this problem. I also ordered this for my mother and I can saw a positive change. She is recovering now and looks more healthy and happy than before.

[joylenecorrea]

Sir why didn't you explained primary systemic amyloidosis

[parinaazkaur]

Sir plz upload more videos to cover such topics..!! Its really helpful..!! I m waiting frm a long time for u to upload more such videos..!! Its a humble request sir plz upload moree..!!

[muskandeshwal]

Sir please please make video on wbc would be very helpful the way you explain and give in depth explanation it gets very easy to understand

[MugeshA-wtkd]

Sir can u give your slides in pdf format to get downloaded.... So that it will be very much usefulll

[monikabehera]

I could totally understand the topic now....thsnks to u sir🤩👍

[jagrajsingh]

My grandfather was suffering from Lichen Amyloidosis. We took him to many doctors but no permanent relief was there. One of my friends told me about Planet Ayurveda, we visited there, consulted Dr. Vikram Chauhan, Dr. Vikram prescribed my father with Amyloidosis care pack. My father is still taking the medicines and he has much relief now.

[rutvikrana]

Plz sir can you share your ppt. It will be very useful during revision of this

[monikabehera]

Plz plz make moreee such videos..its really helpful 🙏😁😇

[shiwanidigital]

Awaysome lecture sir thank you so much sir

[dr.ankitakacha]

superb explained sir 👌🏻👍🏻 waiting for ur more videos on other topics

[albatamboli]

Good afternoon sir. Very well explained sir! Please keep the good work on for us. Thanku sir!