Myasthenia gravis - causes, symptoms, treatment, pathology

Follow us on social:

Our Vision: Everyone who cares for someone will learn by Osmosis.

© 2024 Elsevier. All rights reserved.

[msjdavisxo]

I got it when I was 13. I’m 25 now. I take prednisone, pyridostigmine and I’ve had the thymus gland removal. For me my symptoms has become less and less frequent but it’s not completely gone

[christinahenry]

I am 63 years old and I have been suffering from the weakness periodically from the age of about 16. Every Time I went to a doctor all they wanted to test me for was MS. I was finally diagnosed 6 years ago. When I walked into the Neurologists office my first words to her were, "You are not testing me for MS I do not have MS I have been tested for it for the past 40 years and I don't have it" she told me " No you don't have MS but I do think I know what you do have." She did a neurological evaluation and then did some blood work and told me to come back in a 2 weeks. I was pretty sick at the time, but agreed. I went back and I was actually grey at the time. I was so weak I could barely walk even with the aid of my walker. She told me what I had was Myasthenia Gravis. She explained it to me in language I could understand, and told me I needed to be admitted right away. Well this was 2 days before Christmas and I had 35 people coming for Christmas dinner. I asked if it could wait till after the first of the year. She took one look at me and said you will not be alive at the first of the year, if you don't get treatment. I told her the situation I was in and we agreed I would go in right after Christmas. I was with my daughter in law and we had to stop and get a last minute gift for my grandson, I stayed at the front of the store because I felt so horrible. And to make it even worse people kept stopping and asking if I was okay and did I need an ambulance. Anyway she got the gift and I felt so bad I almost told her to take me back to the doctor so I could go to the hospital. By the time I got home all I could do was fall into a chair. I was beat, and in walks a friend ( one of my daughter in law's uncle's, who just happens to be a chief.) Any way he told me that was now his kitchen and if I wanted anything I was to tell one of my grandchildren and he would get it. Anyway Christmas went off great and I went into the hospital a couple of days later. Then came my first experience with plasmapheresis. I want to tell you, doctors need to know there is more out there then MS. I was beginning to think I was crazy, I even asked my primary care doctor to send me to a psychiatrist, because I had become convinced of it. After a couple of sessions, he revealed that I was not crazy and they symptoms were not in my head.

[ocharranmd]

I am so impressed by the quality of this short video review on a topic that can be challenging to learners. Kudos to you! I am studying for my Pulmonary boards, and this was a neat review of basic science concepts. For other learners out there, don't forget that Myasthenia gravis crises should be treated aggressively with plasmapheresis or IVIG or high dose steroids. Make sure to monitor their respiratory status closely, and consider elective intubation if vital capacity (VC) <20ml/kg or if MIP is worse than -30cm H20 (meaning, if they cannot generate a more negative inspiratory force, then they are impending respiratory failure).

[louise]

I really love your videos! You make it easier to grasp the whole concept of whatever topic you discuss in a few minutes!

[balancedbodypopt]

Excellent video! I'll remember this for my neuropath exam:D

[stepsuntildeath]

Hello I love your videos, you make learning fun but can I suggest a correction? Myasthenia is a Greek word not Latin from Greek "μυς" meaning muscle and "ασθένεια" meaning weakness. Thanks

[Eyram_mela]

Symptoms started at age 15 and I’m 19 now it’s been challenging but I still hope for the best.

[myastheniagamer]

I hate this thing so much I sleep all day because I just can’t get up and I need to sleep sleep sleep sleep and more sleep it just makes it worse I have congenital myasthenia but they are very similar life is so hard and I try my best to power throw it but every day gets harder for me.

[noodletroodle]

I have congenital myasthenia which is kind of like this but I was born with it. From some research I’ve found that it’s very similar to this so this really helped me understand what I have just a bit more thanks :)

[natalierullmanward]

I went to a new job today. Everyone else there was fine, before lunch I became so weak and painful that vomited from the pain. Ive never experienced anything like this. I recently went through 6 full weeks of Shingles and am getting a little concerned (okay alot concerned). I have other auto-immune disease as well, i.e. crohns, hashimotos to name a few.

[TheDarkizer]

i got diagnosed by this. i have thymoma (not yet removed till now), you guys probably won't believe me, but i actually a personal trainer . i've been on physical activities / organisation since age 16 . i got diagnosed at age 24 . i am a guy, not even young woman / old men yet.

my body fat around 11-13 % ( 72 kg, 172 cm, the body fat depend on what i do [cut/bulk] ) . my bench press around 135 kg, i can do front and backflip, i can do tornado kick both front and back foot.

don't give up people, even i diagnosed with this muscle grave sickness, i still can be superior on this physical activities. don't let this sickness take over your life.

[miranmuslem]

Osmosis you deserve all the money I give to my university! Thank you again!

[drfarhankhan]

Not a single word about the Tensilon test (Edrophonium test) ??

[gcvoon]

Does beta blocker causing myasthenia gravis symptom from blocking the muscle receptors?

[nicoleh]

I'll be having my thymectomy this Friday. I was diagnosed last January when I was in crisis state and being in the ICU for 2.5 weeks. After reading these comments, I'm happy to see I'm not alone.

[j.l.c.]

Great video! There is also Seronegative MG (can be confirmed via SFEMG, Tensilon test) and 3 other antibodies that have been recently discovered- these include LRP-4, Agrin, and Cortactin.

[CooperRome]

I am a 13 year old boy. I was born with Myasthenia Gravis. I've always been bullied for my eyes being "crossed". I get double vision all the time and sometimes I black out. I can say, it sucks. My eyes never look quite right. We've tried surgery after surgery and nothing works. Always wondered what they'd look like if my right eye wasn't droopy. That's okay though.

[awaisakhtar]

Great video on the topic although I think it may have been important to note that when treating myasthenia gravis it is important to watch for symptoms of cholinergic poisoning as this can be fatal. When testing for myasthenia gravis one must always carry it out in facilities capable of having respiratory support since one of the symptoms of cholinergic poisoning is paralysis (can impact the lungs and cause resp. paralysis)

[darks]

I got myasthenia when I was 7 yrs old, and I have had my thymus removed at age 8 or 9 and don't take prednisone anymore, but I still take pyridostigmine. I am better, but it's not gone yet and I have had around 3-5 myasthenic crisis, (which were very severe).

[eget]

More treatment options: intravenous immunglobulin (fast effect start), cortisole, some other immunesuppresants.