Acute Myeloid Leukemia (AML) - Auer Rods - Myeloperoxidase Positive - Hematology & Oncology Series

Acute Myeloid Leukemia (AML) | Auer Rods | Myeloperoxidase Positive - Hematology.
Acute Myelogenous Leukemia (AML) is a malignant neoplasm (cancer) of myeloid cell lineage (myeloblasts and monoblasts). It's a leukemia (cancer of the blood and the bone marrow). It affects patients between age 40 and age 60 for the most part. Risk factors for AML include Myelodysplastic syndrome (MDS), Benzene, Ionizing radiation exposure, alkylating agents, antineoplastic agents, aplastic anemia, paroxysmal nocturnal hemoglobinuria, and Fanconi anemia. Myeloblasts and/or monoblasts occupy more than 20% of the bone marrow. It can cause anemia, infections, and platelet clots. AML has many subtypes (e.g. M0, M1, M2, M3, M4, M5, M6, and M7). AML is diagnosed by being TdT negative, Myeloperoxidase (MPO) positive, and a hypercellular bone marrow (on bone marrow aspiration/ bone marrow biopsy).

AML = Acute Myeloid Leukemia (or Acute Myelogenous leukemia).

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[martinezbiz]

My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.

[olamideoludoju]

Your hematology oncology videos are perfect medicosis!
Thank you.
Truly, "medicosis perfectionalis, where medicine makes PERFECT sense".

[yellowishpeony]

Thank you so much, sir! It gives me courage to start reading my actual hematology book, which is kind of dull. I'm once again thanking you for making it easy and fun!

[dr.nesreenibrahim]

I just received my pass result in NBDE part 1exam ...thank you medicosis .your channel helped me a lot in understanding the most hard subjects in pathology.

[gracepepical]

This is so much clearer than in my book. I'm truly grateful for these videos 🙏🏾

[rovoB]

I have no words. For last 3 months I was so damned about this Leukemia and tried several sources to understand it. This was the best ever possible video for it. Thankyou so much sir. In debt

[nandinisingh]

oh my god i cant believe i am finally able to understand these hematology and oncology topics!!! u are s
uch a great teacher!!

[Wishyouendwell]

Never knew I would have so much fun learning patho... I bet it's my fav sub after this .... Thanks a ton

[warunadissanayake]

Its a very simplified version of hematology. Thank you so much.

[gourangomandal]

U r the saviour of medical students thank u so much

[beste]

your voice is very soothing, it doesnt make m feel like i'm listening a lecture video, thank you for your work

[hannahrosa]

Once again you hit it out of the ball park. I wish I'd found you years ago.

[daryllacker]

Great info, my father in law was just diagnosed with aml and this was wonderful to find. For the record he is 84 so the age brackets you define might actually be a little looser.

[donnatinkham]

Thank you for these videos . Patho phys. books can make things so confusing but these videos help breath it down !

[razeed]

came here because of EMMAN NIMEDEZ ... get well soon lodi

[mnaga]

I have exam tmrw and thanks alot for helping me clear up ALL, CLL, AML, CML 👍

[anvayajadhav]

I really loved your video! Thank you so much for teaching it in such a simplified and concise manner.

[EfrahNaz]

Thankyew medicosis I'm addicted to your teaching method..

[mitanshusharma]

Always very Good presentation, easy to learn and understand.

Hats off to your Hard Work

[NuclearMedicine]

Now, its very easy to understand because of simple and clear explanation. Thank you so much...!!!