CC3D WS 2.1: Contact Energy, Cell Adhesion and Cell Sorting [Glazier, Fennell] July 30, 2024

CompuCell3D Workshop Module 2.1 Cell Adhesion, Contact Energy and Cell Sorting, July 30, 2024
Presented by Prof. James A. Glazier, Mr. Hayden Fennell
Indiana University, Department of Intelligent Systems Engineering and Biocomplexity Institute
Bloomington, IN 47408, USA

*Contents*
Types of Energies (Plug-ins) Constraints vs Contact Energy
Cell Shapes
Motivation: Epithelial to Mesenchymal Transition (EMT) and Role in Cancer
Exercise 2.1.1 Simulating a Cell Aggregate
Contact Energy Principles
Contact Energy on Different Lattices
Scaling of Volume and Surface on Lattices
Exercise 2.1.2 Exploring the Effects of Contact Energy
Editing CC3DML
Steering Running Simulations
Exercise 2.1.3 Modeling Epithelial to Mesenchymal Transition
Exercise 2.1.4 Effects of Small Cell-Cell Contact Energies
Exercise 2.1.5 Relationship between Contact Energy and Fluctuations
Exercise 2.1.7 Exploring the Effects of Contact Energy on the Shape of a Single Cell
High Contact Energy
Low and Negative Contact Energy—Fragmentation and Dust
Contact Energy and Neighbor Order
Exercise 2.1.8 Effects of Contact Energy Neighbor Order
Exercise 2.1.9 Cell Sorting
Biology of Cell Sorting
Differential Adhesion Hypothesis
Sorting and Mixing Conditions on Contact Energies
Building the Cell-Sorting Model
Exercise 2.1.10 Exploring Cell Sorting

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