Scale up challenges in bioreactors

This video builds on our series of video on Bioreactors (see playlist) where we discuss important aspects such as design considerations, oxygen transfer rate and uptake rate, and sensors. In this video, I will discuss scale up of bioreactors and what different approaches you can take. As you will see each method has it is own (dis)advantages and the physiological parameters will change once you scale up the bioreactor. At the end of each video, you should know common methods of scale up and compare them against each other and be able to make an informed decision depending on the scenario (for instance cell culture used).

[mariamahmed]

Thank you for the video, I took practical lesson on the mechanism of bioreactors when I studied food fermentation in my undergraduate programme.

[tinailc]

Thank you very much for all of your excellent bioprocessing videos! You mention towards the end of the video the simple geometric scaling of airlift bioreactors. Could you recommend any undergrad-level literature on the subject? Textbooks abound with STR scale-up examples, but I could not find much on the subject of airlift bioreactors!

[taniat]

Hi, in 06.14 you mentioned if you keep N constant, P/V would decreased, hence the oxygen transfer within the liquid would also decreased. But is it not the other way around? From the table, If we keep N constant (N=1) during scale-up, then P/V value increases from 1 to 25. Also, the same case, if we keep P/V constant then wouldn't N value decreased from 1 to 0.34?

Please let me know if I was mistaken cos I am a bit confused now.
Thank you for the video!