5. Hallmarks of cancer (part 2)

The hallmarks of cancer are the 6 key traits that cancer cells share in common; they are the properties that make them cancerous. In the previous video we learned about the first two - self sustained growth and insensitivity to anti-growth signals.

In this video we cover the last 4:

Tissue invasion and metastasis: cancerous cell need to be able to break free of the extracellular matrix in tissues, enter the bloodstream or lymphatics, leave the blood stream and seed in another tissue/organ.

Sustained angiogenesis: as cancers grow, they need to keep a steady supply of nutrients. This means stimulating processes that lead to the growth of new blood vessels that are able to supply them with their nutritional needs.

Avoiding apoptosis: cells which have damaged DNA are normally detected and mechanisms lead them to self destruct in order to avoid passing on mutations to their daughter cells. Mutations in genes coding for proteins involved in this process can allow cancerous cells to ignore these signals.

A more recent version of the hallmarks of cancer have added a further 4 hallmarks (making 10 in total) - these will be covered in a later video.

References
Hanahan and Weinberg, 2000 The hallmarks of cancer Cell, 100 (2000), pp. 57-70

[swaralikeni]

Can u plz upload another video explaining 4 new hallmarks of cancer...and the video was really helpful ...ty

[assetgabriel]

Very nice animation and explanations! It would also be better if sounds can be louder :) Thank you so much!

[zoetaguma]

These videos are so so helpful and easy to understand. Thank you!

[belaliamelouka]

I'm so lucky cause I have found these vds
Thank you sir 🙏

[Ako_]

Hey, thanks for your videos, I really find them useful. Keep up the great job.

[sarahmansournejad]

Thanks for simple and detailed explanation 😍

[hyaenodon]

I feel like this series overemphasised the role of DNA in the types of signal transduction dysfunction possible in cancerous tissues. Perhaps it would be helpful to mention protein folding (redox or glycosylation), and or protein transport, to ensure enquiring thought on the issue. Definitely my favourite hallmarks video though, I learned a lot.

[sjarah]

Did u upload the other video covering the rest of recent hallmarks yet?

[amelial]

Hi I would like to ask, does the part 1 + part 2 video of the hallmarks of cancer cover the full research paper by Hanahan and Weinberg? Thanks, great video

[bombasticcubic]

good animation and explanation! thanks (:

[Kyrani]

Aren't these the hallmarks of stem cells?

[turkiabdulmohsen]

صوتك يجيب المغص وانت تكحكح جمب المايك و تبلع ريقك اشرح زي القنوات الثانيه بليز وشكرا مفيد جدا