Dr. Doron Sher - 'Understanding Ketones'

Dr. Doron Sher completed his medical degree at the University of New South Wales in 1991. Following this he completed a Masters Degree in Biomedical Engineering. His research thesis on Anterior Cruciate Ligament Reconstruction won the Evelyn Hamilton Memorial prize from the Australian Orthopaedic Association.

Dr. Sher's Orthopaedic training was completed on the Sydney Orthopaedic Training Scheme. Following this he travelled overseas for 18 months undertaking sub-speciality fellowships in The United States, Canada and Italy where he worked with many of the world's leading surgeons. He is also the former Head of the Department of Orthopaedics at Concord Repatriation Hospital.

Dr. Sher developed an interest in low carbohydrate nutrition after discovering the ineffectiveness of traditional diets in helping his patients lose weight and avoid surgery. His passion for helping patients avoid unnecessary surgery has led to his involvement in two successful metabolic, arthritis, weight loss and sports performance clinics.

[kathleenoneill]

Clearest explanation of the mechanism of ketosis I’ve heard yet. Thank you!

[anemicgoalhop]

His two lectures are the best presentations of the basics of metabolism I've heard.

[Vccine]

I really enjoy the simplicity and clarity of these presentations, very easy to understand for people with no scientific background.

[paulhorowitz]

A real doctor vs a chiropractor or someone trying to sell me supplements or bone broth educating me on ketones.

So refreshing!!

[Jefferdaughter]

19:05 - According to one of the other talks on YT (on one of the keto, low carb, Acestral Healt or Paleo channels) protein DOES NOT spike insulin levels IF eaten without carboydrates, or in a fasted state. Sorry I don't recall which speaker reported this, but it is worth checking out. Especially since many people don't get enough protein, especially those over +/- 65 yrs, and the very young. (No wonder, with sugary, starchy foods and drinks being pushed for children. And now we know those grain-based cereals, snack bars, etc are contaminated with significant levels of glyphosate.)

[MrAutospec]

Oh my god! That is great explaination ! Thank you Doctor!

[vivamaricica]

I'm dependent of this channel. Thanks! :D

[carrollhoagland]

Indeed Dr Sher - Food is a general term, in reality it is Chemical Information for the body and each molecule of food has the potential to be a building block, an antagonist, and directly interact with DNA, mitochondrial RNA, and all metabolic pathways."

[ruthlesskumquat]

So basically what he is saying is that ketone production can't happen without gluconeogenesis. Deprive the body of carbs then it has to get glucose from the oxidization of oxyloacetate and because of that we get an increase in Acetyl CoA and the increase in Acetyl CoA results in the production of ketone bodies. Hmm very interesting.

[Rose]

thank you Dr. this was superbe information :)

[sarap]

This is very interesting about this I would love to tried some of these ketones

[timhalcomb]

Thank you for posting very informative

[johnx]

That was a great presentation. The quick setup was brilliant and the subject was covered comprehensively at a very useful level. I have been using and studying this system since the early 90's and this has encapsulated almost everything. Just wondering - why is Glucogon not mentioned?

[zeppelinqaz]

You don't have to eat more fat to get into ketosis, fasting will achieve the same thing. Just do an 18:6 diet or 24 hours fast.

I stop eating at 8:00 PM and skip breakfast the next day and eat at 12:00pm I have a small number of carbs and medium protein and fat. For dinner a medium amount of carbs, some protein and fat.

My weight is low and my numbers are good, and I have no concerns about the long-term effects of eating too much fat .

[acefalcon]

Explained well and easy to understand, thank you

[CommunistKiro]

I still don't get how much insulin is vital to the functioning of the body during nutr. ketosis. As a type 1 diabetic should one reduce their slower acting insulin dose to facilitate and not inhibit ketosis, and if so, by how much depending on the length of the fast?

[bonniespruin]

What happens if you get stomach pain from too much fat? If I eat chicken skin two days in a row, it feels like someone punched my gut. I have leaky gut and had pancreatitis years ago after giving birth to twins. I was only 100 pounds (it was normal for me, I'm very small) and went up to 147 pounds (the boys were 6 and 7 pounds when they were born). I'm trying to get rid of gut pain and eat low carb. I can't digest fat very well. I'm already using digestive enzymes. With my supper, I'm taking a supplement that has (along with other enzymes) 80 mg of lipase (I take 2). I also have reactive hypoglycemia and adrenal fatigue.

[MrHazelglen]

There are so many brilliant minds in this space but not everyone can explain the science so a dumbass like myself can follow along, thanks for taking the time to explain to a general audience and not just your colleagues. I know this works because it has worked for me now I have a better understanding why.

[ramachandranchandrasekhar]

How does the drug Metformin (introduced initially as appetite suppressant/weight loss medicine before it became a standard diabetes
Medicine) intervene with Ketone production in the liver?

[petercyr]

IMO, our big brain is the main reason we make so many ketones. Other mammals dont make a lot of ketones. To be healthy you have to be a fat burner and produce ketones. Dont block ketone production with a high carb diet.