Chemical kinetics in coacervate droplets - Karina Nakashima

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Karina Nakashima - University of Cambridge
Thu Oct 17, 10h30 CET

Coacervate droplets are liquid aggregates formed spontaneously through liquid-liquid phase separation, first studied by Bungenberg de Jong. These supramolecular structures provided a model to Oparin and Haldane’s hypothesis that, at the origin of life, molecules came together in microspheres suspended in the primeval ocean, facilitating further reactions - a form of physical autocatalysis. I will discuss the distinct features of chemical reactions in the presence of coacervate droplets – both in terms of reaction kinetics and in terms of droplet dynamics.

References:
[6] Coacervation (Partial miscibility in colloid systems) (1929), PKNAW 32.
[7] Germline P granules are liquid droplets that localize by controlled dissolution/condensation (2009), Science. Clifford P Brangwynne, Christian R Eckmann, David S Courson, Agata Rybarska, Carsten Hoege, Jöbin Gharakhani, Frank Jülicher, Anthony A Hyman.
[8] Widespread occurrence of the droplet state of proteins in the human proteome (2020), PNAS.
[9] Biomolecular condensates: organizers of cellular biochemistry (2017), Nat Rev Mol Cell Bio.
Salman F. Banani, Hyun O. Lee, Anthony A. Hyman & Michael K. Rosen
[11] Growth and division of active droplets provides a model for protocells (2017), Nat Phys,
David Zwicker, Rabea Seyboldt, Christoph A. Weber, Anthony A. Hyman & Frank Jülicher
[14] Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life (2021), Nat Commun, Muneyuki Matsuo & Kensuke Kurihara,
[15] Multispecies autocatalytic RNA reaction networks in coacervates (2023), Commun Chem 2023
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