1) Adeno Associated Virus (AAV) - An Introduction

Adeno Associated Virus (AAV) is a new gene delivery system that is ideal for gene therapy. They are small and relatively simple viruses that have broad host range, and their apparent lack of pathogenicity and low immunogenicity increase their potential as viruses for gene therapy.

Adeno-associated viruses offer numerous advantages over Lentivirus and Adenovirus gene delivery systems. The numerous AAV serotypes allow viral infection in virtually all tissue types, and its ability to infect both the dividing and quiescent cells makes them a great gene delivery tool for genome editing applications, such as CRISPR-Cas9 knock out. In this video, we will introduce some key features of adeno-associated viruses and briefly and go over its pros and cons as a genome editing tool.

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[sangeethvaheesan]

Great video, very simple and to the point, makes researching further a simple process without complicating the process. Thankyou.

[kathyc]

Great explanation, thank you so much! I wish it was possible to mute the music.

[TheGanjam]

Excellent video. Many thanks.
 Could you please also add a video on how to quantify AAV by real time pcr step wise.
Cheers ;))

[goes.]

So is the transgene delivered in the adenovirus or the AAV? is the only genetic material in the AAV the rep and cap proteins?

[izzaimran]

itd be really nice if there were subtitles for this video!

[xzaviormilton]

Can you do gene therapy with influenza a virus vector ?

[aswang]

In the tropism slide, you verbally mention AAV 9 but did not describe its tropism.

[bdhome]

I want to explore genetic engineering from basic to research level. Can you provide me a guideline?

[mauriziocelentano]

The background music is annoying and covers the speaker's voice.

[userou-igze]

please mute music. please don't confuse shavers and microphones. Thx, the internets

[dramirfarhadbahreini]

Waw I appreciate the luciferase Dr Farhad Bahraini from Russia academy of medical sciences

[NamasenITN]

Audio is suboptimal and English pronunciation is not always very clear.