THE LENSKI EXPERIMENT w/ Andrew Fabich PhD | 2021

This is a critical look into the Lenski Experiment which began in 1988. Thus far Richard Lenski and colleagues have been able to simulate over 1 million years of e-coli evolution. Here, with much respect to Lenski, we look into the possible issues with the experiment. We will also discuss origin of life, and the beauty of nature even at the microscopic level. This interview will blow your mind, so watch till the end!

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❗DISCLAIMER❗: The views and positions held by guests do not necessarily represent the views of Jonathan Guzman.
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[williamedwardhackman]

Great podcast video Jonthan Guzman Amen.

[CreationMyths]

With respect to Dr. Fabich, I don’t understand the critique involving the choice of media. It doesn’t change anything about the complexity of the Cit+ trait.

Mutators are interesting because the lineage explores sequence space more rapidly, which allows them to “find” those subsequent mutations more readily.

The Cit+ mutations are *not* just changing a promoter. It’s duplicating the citT gene, plus up-regulating an succinate importer, and changing acetate metabolism as well. It’s a completely different biochemical arrangement relative to the ancestral state. And my favorite part is that some of the “potentiating” mutations, which are initially neutral, and then become beneficial in the context of the citT duplication are actually deleterious due to epistasis with subsequent mutations that optimize citrate metabolism, which leads to selection for a different set of mutations in the same genes as the original potentiating mutations. It’s an extremely complex dance.

Last thing: convergence doesn’t undermine the finding in some way. It just shows how complex traits can evolve pretty readily.