Science Spotlight - Targeting Cellular Senescence in Cancer and Beyond | Memorial Sloan Kettering

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MSK cancer biologist Scott Lowe, PhD, delivers his MSK Science Spotlight lecture on April 13, 2020.

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Автор

I really enjoyed this - I used to work on cellular senescence and had a paper ready to publish but alas, it never came to pass! Nice input from Dr Lowe.

StrategicSourcingProcurement
Автор

Why would you want to put cancer cells into senescense?? That's a temporary fix and usually results in inevitable relapses and chemoresistance. There's substantial data that shows that most chemotherapies actually induce senescence in a good portion of cancer cells which ultimately leads to recurrences and/or resistance. Why not study universal senolytics which target cancer cells since BOTH senescent cells and cancer cells share many similarities (morphologically and mutation burden). There are already such senolytics being studied such as FOXO4 blockers by Cleara Biotech and other broad spectrul senolutics with profound anti-tumor effects (EF-24 among others).

vitaminboss