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Chromosomal Basis of Inherited Disorders | Modern Understandings of Inheritance | Unit 3. Genetics
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Chapter: Chromosomal Basis of Inherited Disorders
Collection: Modern Understandings of Inheritance
Unit 3. Genetics
Book: Biology
Read the 'Chromosomal Basis of Inherited Disorders' chapter online at:
Check your comprehension by answering those online MCQ questions:
The number, size, shape, and banding pattern of chromosomes make them easily identifiable in a karyogram and allows for the assessment of many chromosomal abnormalities. Disorders in chromosome number, or aneuploidies, are typically lethal to the embryo, although a few trisomic genotypes are viable. Because of X inactivation, aberrations in sex chromosomes typically have milder phenotypic effects. Aneuploidies also include instances in which segments of a chromosome are duplicated or deleted. Chromosome structures may also be rearranged, for example by inversion or translocation. Both of these aberrations can result in problematic phenotypic effects. Because they force chromosomes to assume unnatural topologies during meiosis, inversions and translocations are often associated with reduced fertility because of the likelihood of nondisjunction.
00:00 Chromosomal Basis of Inherited Disorders
00:29 Identification of chromosomes
02:40 Career connection
06:23 Disorders in chromosome number
07:47 Aneuploidy
09:51 Polyploidy
10:55 Sex chromosome nondisjunction in humans
14:28 Duplications and deletions
15:19 Chromosomal structural rearrangements
15:58 Chromosome inversions
17:47 Evolution connection
20:19 Translocations
21:01 Section summary
©Copyright 2022 Jobilize LLC all rights reserved.
Collection: Modern Understandings of Inheritance
Unit 3. Genetics
Book: Biology
Read the 'Chromosomal Basis of Inherited Disorders' chapter online at:
Check your comprehension by answering those online MCQ questions:
The number, size, shape, and banding pattern of chromosomes make them easily identifiable in a karyogram and allows for the assessment of many chromosomal abnormalities. Disorders in chromosome number, or aneuploidies, are typically lethal to the embryo, although a few trisomic genotypes are viable. Because of X inactivation, aberrations in sex chromosomes typically have milder phenotypic effects. Aneuploidies also include instances in which segments of a chromosome are duplicated or deleted. Chromosome structures may also be rearranged, for example by inversion or translocation. Both of these aberrations can result in problematic phenotypic effects. Because they force chromosomes to assume unnatural topologies during meiosis, inversions and translocations are often associated with reduced fertility because of the likelihood of nondisjunction.
00:00 Chromosomal Basis of Inherited Disorders
00:29 Identification of chromosomes
02:40 Career connection
06:23 Disorders in chromosome number
07:47 Aneuploidy
09:51 Polyploidy
10:55 Sex chromosome nondisjunction in humans
14:28 Duplications and deletions
15:19 Chromosomal structural rearrangements
15:58 Chromosome inversions
17:47 Evolution connection
20:19 Translocations
21:01 Section summary
©Copyright 2022 Jobilize LLC all rights reserved.
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