COVID-19 Insights: Hypercoagulability (Clotting) Role of the ACE2 Enzyme - Part 1

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. ACE2 Enzyme and COVID-19 Hypercoagulability - Part 1

Generation of Ang 1-7

Ang (1-7) receptors (MAS Receptors)

MAS Receptor history and the reason for its name

Ang (1-7)
Angiotensin-(1–7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-κB-dependent pathways

What is a superoxide radical?

Vasoconstriction by Angiotensin II
Cellular Mechanism of Vasoconstriction Induced by Angiotensin II
It Remains To Be Determined

Angiotensin II pro-inflammatory effect

NADPH Oxidase (NOX) with Ang II

Function of NADPH Oxidase

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

[ArtfullyMusingLaura]

This was great, thank you so much. I watched the MedCram video yesterday, which covered the backend production of radicals from the mitochondrial Kreb cycle, converting proteins all the way through to how the radicals are created and then how the body deals with neutralizing them with the SODs and GPx enzymes. Your video then took it further to connect it to the inflammation and clothing issue and how ACE2 also deals with the radicals with the ANG 1, 7 production. MedCrams video speculated that people with underlying health conditions that may already have deficient or non-existent SODs and GPx enzyme production, so all they have is ACE2 to deal with the radicals would love to know what you think of that. Here is hoping your right because I am taking an ACE receptor drug.

[jennyeyles]

I'm not a medic but find your videos very informative. I have Antiphospholipid Syndrome and I'm am learning much that relates to my autoimmunity as well as to Sars-CoV2. I shared the video on Twitter as a big Thank-you

[kalpeshpatil]

Amazing sir....👌👌👌
What a Thanks so much educating everyone n for ur efforts....🙏🙏🙏

[marynguyen]

Absolutely love your video, it really consolidated my understandings of the pathophysiology of covid19. You are a grear lecture who knows how to clarify these very confusing concepts of the Renin- Angiotensis pathway.

[thomasfraser]

Hi Doc as a retired RN I absolutely love your lectures and learning far more about viruses then I ever did in nursing school years ago.

I am responding to this particular lecture because I want you to know that I have been on CoQ10 for over 40 years. And I think it has sustained my life over both my father and my younger brother who both died of a heart attack at 60 years old.

I am now 72 with diet controlled diabetes and a status post double bypass heart surgery for the Widow Maker in 2018 with no sustained heart damage. Why am I bringing up CoQ10

In a Study. "Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin Converting Enzymes in Patients with Acute Coronary Syndrome" it was found that treatment with Q10 in heart failure prevents myocardial cell damage and repairs the age related lost of Q10 deficiency in both blood and myocardial tissue resulting in significant improvement in heart failure.

Since Q10 is easily accessible for all to take orally and is a regenerable, bioenergetic, a powerful antioxidant and an ATP sparing agent capable of protecting cell structures from oxidative damage during ischemia and reperfusion injury [21, 22]. It makes sense to me that in this time of Covid19 outbreak everyone should run to Walmart and take it every day. Would you agree?? Cheers

[hassinayazid]

Say thank you it’s not enough for you . You deserve a lot of respect!
God bless you!

[rosesacks]

Glad to see all the reference sources you list. Thank you

[donilonop]

Thank you so much Dr, this is the best explanation regarding hypercoagubility in covid .

[bababee.]

Salam! Thank you Sir for a clear and wonderful explanation. Allah bless you. From Philippines here.

[moumoubench]

Great explanation thank you doctor from algeria

[eelkeaptroot]

Thanks, doc another in depth explaination.

[toddr]

Some initial thoughts might be a consideration towards amlodipine as one potential adjunctive treatment by inhibiting the influx of calcium into vascular smooth muscle and increasing nitrous oxide availability to counteract unopposed Angiotensin II. That is in addition to, of course, decreasing angiotensin II through ACE-Is as preferable over ARBs, as you state. I look forward to your lecture on hypercoaguability, and God bless. There is still the matter of ROS.

[danaandrus]

Thank you Dr Mobeen for another great presentation. You are very kind to share your time and thoughts with us all. I still cannot understand why ACE 2 - the enzyme - is present on the alveolar side of the lung cell when it's action is to work on AT 2 in the blood and convert it to AT (1, 7). What's it doing there? Am I wrong in thinking that the virus gains access by attaching to an ACE 2 receptor on the apical side of a pneumocyte?

[oibal]

I watched the MedCram vid on pretty much the same subject. THIS presentation gave me the "AHA!" moment.
AT2 and AT1, 7 IMBALANCE with the knock-on effect of ACE2 receptors becoming 'negated' (as a result of Covid19 virus passing its RNA into the cell), and, in the meantime, within the cell, replication is taking place, so as to, then, 'promote' this imbalance even further by 'sharing' via the bloodstream.
What a beautiful, intricate, mechanism and yet, oh so devious.

[were_all_fact]

What makes AT2 bind with ACE over ACE2 (without the virus being in the body for arguments sake)? ROS is that why the Chinese were flooding the body with IV Vitamin C ~24000mg I believe I read somewhere. Another nice video thanks for the diagrams and reiterating mechanisms, my brain is a slow absorber.

[dennisgarber]

Wow, this was good. You do such a great job of explaining things. I do not get why there are not more thumbs My only question is if you gave an Ace 2 receptor blocker why it would not block virus entry. And, what about any benefits of giving ARB and Ace inhibitor at the same time, in right dose so that they still have blood pressure?

[threeMetreJim]

How about Angiotensin II causing release of ADH, which further increases blood pressure, and causing a positive feedback loop (actually looking again that wouldn't be correct, as lower blood pressure makes more 'scissors', not higher. You'd get less from higher blood pressure, and that goes against positive feedback but people with higher blood pressure are already at greater risk). What can increase the effect of NO? Been around for a while - sildenafil (an odd treatment though).
It's interesting to note what the receptors for ADH/AVP do too, look at AVPR1B and AVPR3 - according to Wikipedia, interpretation of olfactory cues (loss of smell?). The other receptors promote release of von willebrand factor and other blood clotting factors, among other things.
If you look at what vaptans are used for, it seems all of the things that are major contributors to negative covid-19 outcomes. (vaprisol is the non selective antagonist).
Easy to confirm: test patients for increased ADH levels, do they suffer urine retention, etc...

[piotrwojdelko]

there was a time when doctors called to use paracetamol for coronavirus from your explanation i understand that the best will be aspirin, because it has antiinflamatory effect and dilute the blood.

[dranildev]

Thank you so much sir....
Your lecture is very good and informative.

[dr.ruchibanthia]

It is mesmerizing as ang II causes vaso constriction and its proinflammatory.... But first step in inflammation is vasodilatation...
Contradictory...
Same happens with ang 1-7which causes vasodilation and these are anti inflamm