Webinar #4 – From Candidate Genes to Causal Variants.

From Candidate Genes to Causal Variants—Strategies for and Examples of Identifying Genes and Sequence Variants in Rodent Populations.

Goals of this webinar (candidate genes to causal variants):

To understand when it is practical or (just as often) not practical to try to "clone" the gene or nucleotide variant modulating trait variants

To understand that defining the crucial causal nucleotide variant is usually a bonus and often not for the translational or even mechanistic utility of discoveries.

To review new sequence-based methods to identify common and rare variants—the reduced complexity cross and epoch-effects in reference populations