TARGET-HPV: HB-200, a HPV16-specific immunotherapy, in oropharyngeal cancer

Ari Rosenberg, MD, University of Chicago, Chicago, IL, discusses the Phase I TARGET-HPV dose escalation study (NCT05108870) of neoadjuvant HB-200 with chemotherapy in non-metastatic HPV16+ oropharyngeal cancer (OPC). HB-200, an arenavirus-based vector therapy, demonstrated safety and feasibility with an early efficacy signal, showing deep responses in a majority of patients. Responses were particularly notable in those treated with higher doses. The study highlights the potential of HB-200 with chemotherapy in the treatment of OPC, warranting further investigation in randomized Phase II trials. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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