OBD Guest Speaker Prof Takeshi Iwatsubo (long version).

It was a pleasure to welcome Professor Takeshi Iwatsubo to our guest speaker series. Takeshi Iwatsubo is a professor of neuropathology at the School of Medicine, University of Tokyo. Originally trained as a neurologist and neuropathologist, he has contributed to the studies of human neurodegenerative disorders, especially Alzheimer's (AD) and Parkinson's disease, using multidisciplinary approaches.

Professor Takeshi Iwatsubo provides a comprehensive review of the J-ADNI project and the insights to date.He further expanded on his laboratory's role to build a Japanese Trial Ready Cohort for preclinical/prodomal AD (J-TRAC). Progress is being made already with this approach, starting enrollment with the AHEAD, Trailblazer ALZ3 and other preclinical AD trials.

00:00 - Welcome
04:05 - Introduction to J-ADNI
10:20 - J-ADNI Data
15:47 - Comparison of baseline data from J-ADNI and North American ADNI
21:12 - Progression from MCI to dementia
25:25 - J-ADNI2/AMED Study
28:50 - Prevention trials and trial-ready cohorts
39:00 - Predicting amyloid risk
40:30 - Summary
44:50 - Q&A, population differences
48:35 - Q&A, J-TRC substudies
53:12 - Q&A, co-pathologies
56:48 - Q&A, imaging vs fluid biomarkers
58:53 - Q&A, perspective on the amyloid hypothesis
1:01:35 - Q&A, brain health