28 Nov 2018: He Jiankui presentation and Q&A, International Summit on Human Genome Editing [4K]

Paper: "CC5R gene editing in mouse, monkey and human embryos using CRISP/Cas9"

Dr. He Jiankui et al. documents:
1. Slides from the "Second International Summit on Human Genome Editing", 28 Nov 2018
2. Draft Ethical Principles for Therapeutic Assisted Reproductive Technologies by He, J et al., CRISPR J 2018; fast track. DOI: 10.1089/crispr.2018.0051
3. Medical Ethics Approval Application Form, HarMoniCare Shenzhen Women's and Children's Hospital, 2017.
4. Long-term health follow-up plan, Supplementary explanation of informed consent, Nov 2018

Dedication: May Lulu, Nana and their families be well and happy.

[invreview]

Book titled "CRISPR People: The Science and Ethics of Editing Humans" (Professor Henry Greely, 2021)

[invreview]

"Clinical trials using heritable genome editing should be permitted only within a robust and effective regulatory framework that encompasses:
1. the absence of reasonable alternatives;
2. restriction to preventing a serious disease or condition;
3. restriction to editing genes that have been convincingly demonstrated to cause or to strongly predispose to that disease or condition;
4. restriction to converting such genes to versions that are prevalent in the population and are known to be associated with ordinary health with little or no evidence of adverse effects;
5. the availability of credible preclinical and/or clinical data on risks and potential health benefits of the procedures;
6. ongoing, rigorous oversight during clinical trials of the effects of the procedure on the health and safety of the research participants;
7. comprehensive plans for long-term, multigenerational followup that still respect personal autonomy;
8. maximum transparency consistent with patient privacy;
9. continued reassessment of both health and societal benefits and risks, with broad ongoing participation and input by the public; and
10. reliable oversight mechanisms to prevent extension to uses other than preventing a serious disease or condition."