Your Unstoppable Copy Machine｜DNA Replication

DNA Replication is the molecular ground floor of life on Earth. Let's explore your Replisome--an incredible complex of molecular workers that fully copy your genome every time your cells divide.

Clockwork is produced using real molecular data thanks to the brilliant Molecular Nodes extension for Blender:
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🧬Primary Structures Cited:

Core Replisome Structure:

CMG Helicase in Motion:

DNA Polymerase Epsilon:

Primosome:

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[HUEHUEUHEPony]

him :"I'd like to make more frequent videos"
him: *dissapears for 3 years*

[nefex]

I am so grateful that you’ve started doing these videos again. They’re truly incredible. I love the teaching and the existential thoughts. ❤

[fernandojorge]

Nice, I found this channel a couple of months ago and was sad to see all videos were years old, but here it is. Great timing

[FlipYourLearning]

You just made the best video about replication on all of YouTube. The depth of a university lecture with the visual quality of WEHI and the friendly didactic refinement of Ninja Nerd.
Replication made me fall in love with Biology (and teaching). It seemed so complex and random at first, but I challenged myself to teach it on a video trying to make it make sense (so it could be understood, and not just memorized), and then I discovered that everything has a reason in Biology. I'm very happy that someone who feels like a soulmate in regards to the passion for teaching science also has the modelling and animation skills and motivation to make these videos. So glad you're back and better than ever.

[TojiFushigoroWasTaken]

14:09 that sentence was so beautiful, it brought tears to my eye. I promise you my cells, i am and i wont let you down

[olahafs]

This channel is gonna blow the fuck up. There are a lot of people that need this level of biochem

[rileymckinley]

The name change is so right, because so many times i tried to look this channel up and could never remember if it was This Elegant Mechanism, or Our Beautiful Vehicles or what

[xydya]

I can't get over these visuals! Such a better way to see these tiny machines.

[skyethewylder]

I am blown away at the intelligence it took to figure all of this out. I could have really used this visual back when I took genetics in uni.

[maxwoods]

When you stopped making videos I was so sad.
Thanks for making thease!!!!
And I hope it works out better for you this time around!!

[Warninn]

I dont understand how you get so little recognition this world is not fair

[samstarlight]

I don't know why, but the nucleotide just face-planting and falling at 8:52 got a chuckle out of me XD

[adityabanerjee]

I'M SOO GLAD U CAME BACK UR VIDEOS ARE AN HONOUR TO WATCH FOR U ARE BOUND TO BE CONSISTENT AND NEVER LOOSE HOPE...AND REMEMBER I WILL ALWAYS BE A FAN OF UR CHANNEL

[yfarrell]

This is incredibly well done. Your graphics and modeling pair so well with your teaching style. These systems are so complex it’s easy to get overwhelmed with all the parts and minutiae. You keep the main idea flowing through to it’s end. Nice!

[AdarshRadhakrishnan-id]

I absolutely adore your storytelling. THIS is how biology should be taught - as a medium for profound explanation of nearly everything we take for granted yet underlying incredibly interesting phenomena, inspiring curiosity and awe! Please keep going!!

[OzGoober]

I absolutely love that you have pointed out that the trillions of actions of replication happening in me right now, have been pretty much doing that for billions of years. Excellent stuff.

[lunkel]

One thing I am a bit surprised you didn't mention is the proofreading ability of the polymerases. Both polymerase ε and δ have the ability to recognize incorrect bases that were mistakenly incorporated (which does rarely happen), move the DNA over to an exonuclease site to remove the incorrect base and then continue with replication. This improves the accuracy by a factor of something like 100-1000x!

[designsbyphilip]

This should taught in biology in high school. It makes you think and consider the ramifications of the complexity of life itself.

[raijutama]

you returned after 3 years and dropped this banger out of nowhere, welcome back my man!

[lauradftba]

I found this channel senior year of high school when I was trying to decide my major. These videos inspired to choose biochemistry and now I finished biochem 2 last semester, have been working full time in a biochem research lab this summer, and am working on grad school apps to submit this fall. Here’s to all that’s still out there to learn and here’s to you for these incredible videos!