Pain Transduction (Described Concisely)

This video describes pain transduction which is the mechanism by which nociceptors depolarize to reach threshold, so that a pain signal can be transmitted to the brain. When the signal reaches the brain, the person becomes consciously aware they are in pain - this is called perception.

[calpolyca]

I've been looking for the past week for a video to explain, in detail and so that it is understandable, what happens at the nocireceptor level. Nobody was able to provide this until this video. I wish I would've found you first! Thank you so much! I'm a fan now!

[vilasgowler]

What a great video explaining the details of nociception. It is crisp and clear and to the point. Brilliant job

[Rene-uzeb]

3:21 two ways potassium may be involved in chronic pain:
Chronic pain is very common in CKD. So since CKD also causes hyperkalemia by insufficient excretion of potassium, which we know leads to earlier depolarization, it stands to reason hyperkalemia might be directly responsible for chronic pain.

I’m new to the details of potassium channels, but it seems they are involved in maladaptive pain (chronic pain) - by not working, thereby keeping the action potential running longer until repolarization.

“it has been known for some time that nerve injury results in a dramatic decrease in K+ conductance of peripheral nerves that correlates with the emergence of hyperexcitability”

Opening paths to novel analgesics: the role of potassium channels in chronic pain, 2014

[leonardocellino]

Really good vid. Would be really cool if you had more videos on the other stages of nociception too

[salmanibrahim]

Indeed this is a great video on the topic

[KD-mhxv]

Thank you so much. I am studying the senses and I find the nervous system is very complicated regarding touch, pain, light, etc. There aren't many videos about the transduction and transmission of these stimuli which is frustrating because my books don't explain it well.

[josetrujillo]

Holy guacamole! That was a ver desirable presentation. Thank You sincerely

[viv]

so helpful :)

Thank you for the high quality of the explanation

[asoom]

Thank you so much This video is very useful

[sanjaisrao]

Thankyou very much...it was very useful..

[jameshowlett]

Can u please make a video on Necrosis and it's types

[riteshchaurasia]

How capsaicin cream desensitized pain..?when itncausesmpain by opening vallanoid receptor causing influx of na and .ca..plz explain

[ATA-wilh]

Can the same neuron have multiple types of pain receptors? Ex, C5 on the dermatome map. Do C5 neurons contain all the pain/sensation modalities or is C5 composed of different neurons that sense different modalities?