Why Negative Binomial is used in DESeq2?

Most plot you saw here are actually done in RStudio :)

With how well the previous relaxing video is received from the public, I have decided to make another video in the style. but i would say this is possible the most complicated video i have ever made in term of technicality and the work required for the visual presentation of the results. Most of the distribution are actually coded from scratch and animated by myself in R Studio.

Host: Brandon Yeo
Writer: Brandon Yeo
Editor: Brandon Yeo

Multiple Stock video from

Imaged used in this video
1. Poisson Disturbution

2. Poisson Equation

3. Binomial Dist

4. Negative binomial Equation

image taken DEseq2 Documentation:
Love, M.I., Huber, W., Anders, S. (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15:550. 10.1186/s13059-014-0550-8

Feel free to download the script and try it our for yourself. :)

Script used in this video

[liquidbrainr]

6:58 **Chi Square is a type of continous ditsturbution

[mhuzzell]

This is a great video, thank you! Also, I think about the square hole video every time I do model selection. Thank you for including that reference!

[maryamsediqi]

Many thanks for your explanation. you explained a statistical topic in a romantic way lol amazing 👍

[sagek]

I am not sure but I was expecting much more than this.

[ricodsanchez]

Hi there, what challenges from gene expression data could discrete mathematics he applied to.

[alex]

The content itself is good but children, animals and women on the video drive me crazy.