Osteomyelitis | Causes & Symptoms | Bone Infection🩺

Osteomyelitis | Causes & Symptoms | Bone Infection🩺

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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬

00:00:00 Introduction
00:01:10 Pyogenic and non-pyogenic Osteomyelitis
00:04:24 Potts disease
00:05:20 Route of entry
00:05:55 Haematogenous spread
00:12:32 Direct extension from neighboring soft tissues
00:17:24 Direct inoculation or implantation on microbes
00:19:10 Recap

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Defining Osteomyelitis (OM); Pyogenic & non-pyogenic infections.
STAPH. AUREUS; most common organism in pyogenic OM & importance of this fact in directing empirical antibiotic therapy.
Mycobacterium Tuberculosis; most common organism in non-pyogenic OM.
POTT'S DISEASE; OM involving vertebrae; common in adults.

Pathophysiology of OM; routes of entry of organism into Bone Marrow (BM):
1-Hematogenous spread/route.
OM in children; long bone internal anatomy explained; significance of involvement of Metaphysis of long bones in OM of children.
Pott’s Disease; vertebral involvement through hematogenous route; Bacteremia.

Routes of entry continued;
2-Direct extension from neighboring Soft Tissue Infections; periosteal breach, example: DIABETIC FOOT ULCER.
Mechanism of development of Diabetic Foot Ulcer: Atherosclerosis & Ischemia, Immunocompromised & Infection, Diabetic Neuropathy & inadvertent repetitive trauma.
Ulcer deepens, leading ultimately to OM.
3-Microbes direct implantation into bone: Penetrating injury, surgery & Open Fractures.
How bacteria destroy Periosteum?
Damaging enzymes, inflammation, Oxygen Free Radicals. Periosteum; being relatively resistant to bacterial damage.

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