Bradykinin | Let the Drama begin!

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High molecular weight kininogen is a plasma protein (alpha globulin) responsible for activating the intrinsic coagulation pathway as well as producing the inflammatory mediator known as bradykinin (via plasma kallikrein).

Plasma kallikrein, in addition to high molecular weight kininogen (HMWK), is responsible for activating factor XII into XIIa.

Kallikrein-Kinin system consists of a kallikrein (plasma kallikrein or tissure kallikrein) producing a kinin (bradykinin in the plasma and kallidin in the tissue).

Angiotensin-converting enzyme (ACE) degrades bradykinin into inactive metabolites.

Books that I use for this series:

[MrRiedemanJACC]

Hmm who else is here to learn about what may be happening to patients with Covid-19?

[boudibla]

Had Pt presenting with angioedema, swelling of the face, progressively occluded airway, respiratory failure and had to be cric. Pt did not respond to epinephrine. Later was found out he had a switch in his HTN meds (ACE-I). The Bradykinin's Storm was not explained to me until then (I am just a paramedic after all) \\\ Thank you Medicosis Perfectionalist.

[Klocksby]

Great video, but a little bit too fast

[Cactusmushrooms]

Am i the only one who literally couldn't catch up to him properly?!

[seyiajayi]

One of worst educational videos on YouTube

[quitbeingIllusion]

Bradykinin increases migraine or nah ????😕